ACSL5 promotes lipid deposition and lipoapoptosis in proximal tubular epithelial cells of diabetic kidney disease

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成果类型：

期刊论文

作者：

Xi, Yiyun;Yang, Ming;Deng, Zebin;Xiong, Xiaofeng;Wei, Ling;...

通讯作者：

Sun, L

作者机构：

[Cai, Juan; Tang, Chengyuan; Sun, Lin; Xi, Yiyun; Yang, Ming] Cent South Univ, Xiangya Hosp 2, Dept Nephrol, Hunan Key Lab Kidney Dis & Blood Purificat, 139 Renmin Middle Rd, Changsha 410000, Hunan, Peoples R China.

[Xi, Yiyun] Univ South China, Changsha Cent Hosp, Hengyang Med Sch, Dept Nephrol & Immunol, Changsha, Hunan, Peoples R China.

[Deng, Zebin] Cent South Univ, Xiangya Hosp 2, Dept Urol, Changsha, Hunan, Peoples R China.

[Xiong, Xiaofeng] Cent South Univ, Xiangya Hosp 2, Dept Ultrasound Diag, Changsha, Peoples R China.

[Wei, Ling] Cent South Univ, Xiangya Hosp 2, Dept Rehabil, Changsha, Hunan, Peoples R China.

通讯机构：

[Sun, L ] C

Cent South Univ, Xiangya Hosp 2, Dept Nephrol, Hunan Key Lab Kidney Dis & Blood Purificat, 139 Renmin Middle Rd, Changsha 410000, Hunan, Peoples R China.

语种：

英文

关键词：

ACSL5;Diabetic kidney disease;Lipoapoptosis;Proximal tubular epithelial cell

期刊：

Molecular and cellular endocrinology

ISSN：

0303-7207

年：

2025

卷：

595

页码：

112418

DOI：

10.1016/j.mce.2024.112418

基金类别：

National Natural Science Foundation of China [20220212]; Natural Science Foundation of Hunan Province [81730018]; [2021JC0003]

机构署名：

本校为其他机构

摘要：

BACKGROUND: Lipoapoptosis in Proximal tubular epithelial cells (PTCs) are substantial in the etiology of diabetic kidney disease (DKD), yet the underlying mechanisms warrant further investigation. Acyl-CoA synthetase long-chain family member 5 (ACSL5) facilitates the formation of acyl-CoA, however, the precise role of ACSL5 in lipoapoptosis of PTCs in DKD remains inconclusive. METHODS: Transcriptomic data analysis identified the hub gene Acsl5 associated with lipid metabolism in DKD. The expression of ACSL5 was examined in high-fat diet/streptozotocin (HFD/STZ)-induced diabetic mice and high g...

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ACSL5 promotes lipid deposition and lipoapoptosis in proximal tubular epithelial cells of diabetic kidney disease

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