Identification of broad neutralizing antibodies against Omicron subvariants from COVID-19 convalescents and vaccine recipients

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成果类型：

期刊论文

作者：

Chen, Jun;Yang, Jing;Chang, Fangfang;Hu, Yabin;Wu, Qian;...

通讯作者：

Qu, XW;Liu, WP;Liu, Wenpei;Li, YP

作者机构：

[Chen, Jun; Qu, Xiaowang] Southern Med Univ, Sch Publ Hlth, Guangzhou 510515, Peoples R China.

[Liu, Wenpei; Yang, Jing] Southern Med Univ, Sch Lab Med & Biotechnol, Guangzhou 510515, Peoples R China.

[Zheng, Xingyu; Zhang, Jian; Liu, Wenpei; Pan, Dong; Liu, Bo; Lu, Rui; Chen, Jun; Wu, Qian; Qu, Xiaowang; Teng, Shishan; Peng, Liting; He, Rongzhang; Hu, Yabin] Univ South China, Peoples Hosp Chenzhou 1, Translat Med Inst, Hengyang Med Sch, Chenzhou 423000, Peoples R China.

[Liu, Yongchen; Li, Yi-Ping; Chang, Fangfang; Wu, Qian; Li, YP] Sun Yat sen Univ, Inst Human Virol, Zhongshan Sch Med, Dept Pathogen Biol & Biosecur, Guangzhou 510080, Peoples R China.

[Liu, Ze] Xiangnan Univ, Sch Nursing, Chenzhou 423000, Peoples R China.

通讯机构：

[Liu, WP ; Qu, XW ; Li, YP ] S

[Liu, WP] U

Southern Med Univ, Sch Publ Hlth, Guangzhou 510515, Peoples R China.

Southern Med Univ, Sch Lab Med & Biotechnol, Guangzhou 510515, Peoples R China.

Univ South China, Peoples Hosp Chenzhou 1, Translat Med Inst, Hengyang Med Sch, Chenzhou 423000, Peoples R China.

语种：

英文

关键词：

HARBOR;NEUTRAL;hereafter

期刊：

中国病毒学：英文版

ISSN：

1674-0769

年：

2023

卷：

期：

页码：

313-316

DOI：

10.1016/j.virs.2023.01.005

基金类别：

supported by the National Natural Science Foundation of China(82061138020,32270996,82102365) The Science and Technology Innovation Program of Hunan Province of China(2022RC3079) the Educational Commission of Hunan Province of China(21A0529) the Natural Science Foundation of Hunan Province of China(2021JJ40006,2022JJ30095) the Clinical Medical Innovation Technology Guide Project of Hunan Province(2021SK50304,2021SK50306 and 2021SK50312) “SC1-PHE-CORONAVIRUS-2020:Advancing knowledge for the clinical and public health response to the 2019-nCoV epidemic”from the European Commission(CORONADX,no.101003562)(to Y-P.L.) approved by the Institutional Ethical Review Board of The Central Hospital of Shaoyang,Hunan Province,China(V.1.0,20200301) The First People's Hospital of Chenzhou,Hunan Province,China(V.3.0,2021001).

机构署名：

本校为通讯机构

院系归属：

医学院

公共卫生学院

摘要：

Dear Editor, Omicron(B.1.1.529)was designated a variant of concern(VOC)on November 26,2021(Callaway,2021),and its subvariants BA.1,BA.2,and BA.3 emerged and circulated almost simultaneously(Desingu et al.,2022).BA.2 was more efficient in transmission and quickly overtook BA.1 to become the variant most frequently detected worldwide(Yamasoba et al.,2022a).Compared to the prototype SARS-CoV-2 spike protein(S),the BA.1 and BA.2 spike proteins harbor more than 30 mu-tations,of which 21 are identical between the two subvariants,while the BA.3 spike differs from BA.1 and BA.2 by 3 mutations in the ...

摘要(中文)：

Dear Editor,Omicron(B.1.1.529)was designated a variant of concern(VOC)on November 26,2021(Callaway,2021),and i...展开更多 Dear Editor,Omicron(B.1.1.529)was designated a variant of concern(VOC)on November 26,2021(Callaway,2021),and its subvariants BA.1,BA.2,and BA.3 emerged and circulated almost simultaneously(Desingu et al.,2022).BA.2 was more efficient in transmission and quickly overtook BA.1 to become the variant most frequently detected worldwide(Yamasoba et al.,2022a).Compared to the prototype SARS-CoV-2 spike protein(S),the BA.1 and BA.2 ...

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Identification of broad neutralizing antibodies against Omicron subvariants from COVID-19 convalescents and vaccine recipients

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