mTOR regulates TLR-induced c-fos and Th1 responses to HBV and HCV vaccines

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成果类型：

期刊论文

作者：

He, Li;Zang, Aiping;Du, Min;Ma, Dapeng;Yuan, Chuanping;...

通讯作者：

Xiao, Hui

作者机构：

[He, Li; Xiong, Sidong] Soochow Univ, Inst Biol & Med Sci, Suzhou 215123, Peoples R China.

[Ma, Dapeng; Du, Min; Xiao, Hui; He, Li; Shi, Huanjing; Yuan, Chuanping; Zhou, Chun; Mu, Jing; Zang, Aiping] Chinese Acad Sci, Inst Pasteur Shanghai, Key Lab Mol Virol & Immunol, Unit Immune Signaling & Regulat, Shanghai 200031, Peoples R China.

[Ma, Dapeng; Xiao, Jianhua] Univ South China, Inst Pathogen Biol, Hengyang 421001, Peoples R China.

[Li, Dapeng; Huang, Zhong; Huang, Xulin] Chinese Acad Sci, Inst Pasteur Shanghai, Key Lab Mol Virol & Immunol, Unit Vaccinol & Antiviral Strategies, Shanghai 200031, Peoples R China.

[Lan, Ke; Deng, Qiang] Chinese Acad Sci, Inst Pasteur Shanghai, Key Lab Mol Virol & Immunol, Unit Tumor Virol, Shanghai 200031, Peoples R China.

通讯机构：

[Xiao, Hui] C

Chinese Acad Sci, Inst Pasteur Shanghai, Key Lab Mol Virol & Immunol, Unit Immune Signaling & Regulat, Shanghai 200031, Peoples R China.

语种：

英文

关键词：

Toll-like receptor (TLR);mTOR;vaccine;hepatitis B virus (HBV);hepatitis C virus (HCV);adjuvant;c-fos

期刊：

中国病毒学：英文版

ISSN：

1674-0769

年：

2015

卷：

期：

页码：

174-189

DOI：

10.1007/s12250-015-3606-3

基金类别：

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [31070779, 31170862, 31100623, 31270917]; National Key laboratory of Virology [2014IOV006]; Chinese Academy of Sciences "100-talent" program; National program for returned oversea talentsScientific Research Foundation for the Returned Overseas Chinese Scholars; CAS/SAFEA International Partnership Program for Creative Research TeamsChinese Academy of Sciences; Shanghai Pasteur foundation

机构署名：

本校为其他机构

院系归属：

医学院

摘要：

Although IL-12 plays a critical role in priming Th1 and cytotoxic T lymphocyte (CTL) responses, Toll-like receptor (TLR) signaling only induces low amounts of IL-12 in dendritic cells and macrophages, implying the existence of stringent regulatory mechanisms. In this study, we sought to uncover the mechanisms underlying TLR-induced IL-12 expression and the Th1 response. By systemic screening, we identified a number of protein kinases involved in the regulation of TLRinduced IL-12 expression. In particular, PI3K, ERK, and mTOR play critical role...

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mTOR regulates TLR-induced c-fos and Th1 responses to HBV and HCV vaccines

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