FGF21 protects human umbilical vein endothelial cells against high glucose-induced apoptosis via PI3K/Akt/Fox3a signaling pathway

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成果类型：

期刊论文

作者：

Guo, Dongmin;Xiao, Lele;Hu, Huijun;Liu, Mihua;Yang, Lu*;...

通讯作者：

Lin, Xiaolong;Yang, Lu

作者机构：

[Guo, Dongmin; Yang, Lu] Univ South China, Inst Cardiovasc Dis, Key Lab Arteriosclerol Hunan Prov, Hengyang City 421001, Hunan, Peoples R China.

[Hu, Huijun; Lin, Xiaolong] Guangzhou Med Univ, Huizhou Peoples Hosp 3, Dept Pathol, Huizhou City 516001, Guangdong, Peoples R China.

[Xiao, Lele] Huzhou Univ, Huzhou City 313000, Zhejiang, Peoples R China.

[Liu, Mihua] Chongqing Med Univ, Affiliated Hosp 2, Ctr Lipid Res, Chongqing 400016, Peoples R China.

[Liu, Mihua] Chongqing Med Univ, Affiliated Hosp 2, Inst Viral Hepatitis,Minist Educ, Key Lab Mol Biol Infect Dis,Dept Infect Dis, Chongqing 400016, Peoples R China.

通讯机构：

[Lin, Xiaolong] G

[Yang, Lu] U

Guangzhou Med Univ, Huizhou Peoples Hosp 3, Dept Pathol, Huizhou City 516001, Guangdong, Peoples R China.

Univ South China, Inst Cardiovasc Dis, Key Lab Arteriosclerol Hunan Prov, Hengyang City 421001, Hunan, Peoples R China.

语种：

英文

关键词：

*Akt;*Apoptosis;*FGF21;*FoxO3a;*Oxidative stress;*eNOS

期刊：

Journal of Diabetes and its Complications

ISSN：

1056-8727

年：

2018

卷：

期：

页码：

729-736

DOI：

10.1016/j.jdiacomp.2018.05.012

基金类别：

Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81600342]; Natural Science Foundation of Hunan ProvinceNatural Science Foundation of Hunan Province [2018113459]; Medical Foundation of Hui Zhou [2015Y134]; Medical Research Foundation of Guangdong Province [A2015620, A2018099]; General project of Hunan Provincial Education Department [16C1392]

机构署名：

本校为第一且通讯机构

院系归属：

医学院

摘要：

Aims: Diabetic macroangiopathy is the main cause of morbidity and mortality in patients with diabetes. Endothelial cell injury is a pathological precondition for diabetic macroangiopathy. Fibroblast growth factor 21 (FGF21) is a key metabolic regulator which has recently been suggested to protect cardiac myocytes and vascular cells against oxidative stress-induced injury in vitro and vivo. In this study, we aimed to investigate the protective capacity of FGF21 in human umbilical vein endothelial cells (HUVECs) against high glucose (HG)-induced apoptosis via phosphatidylinositol-3-kinase/protei...

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FGF21 protects human umbilical vein endothelial cells against high glucose-induced apoptosis via PI3K/Akt/Fox3a signaling pathway

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