SiNPs induce ferroptosis in HUVECs through p38 inhibiting NrF2 pathway

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成果类型：

期刊论文

作者：

Jiang, Xiaojun;Gao, Huiqian;Cao, Yunchang;Chen, Shuting;Huang, Fangfang;...

通讯作者：

Feng, S.

作者机构：

[Feng, Shaolong; Huang, Fangfang; Feng, Yashi; Zhang, Yuqi; Chen, Shuting; Gao, Huiqian; Jiang, Xiaojun] Guilin Med Univ, Sch Publ Hlth, Guangxi Key Lab Environm Expos & Entire Lifecycle, Guilin, Peoples R China.

[Feng, Shaolong; Chen, Shuting; Jiang, Xiaojun] Univ South China, Sch Publ Hlth, Hengyang, Peoples R China.

[Cao, Yunchang] Guilin Med Univ, Sch Intelligent Med & Biotechnol, Dept Mol Biol, Guilin, Peoples R China.

[Feng, Shaolong] Chinese Acad Sci, Guangzhou Inst Geochem, State Key Lab Organ Geochem, Guangzhou, Peoples R China.

通讯机构：

[Feng, S.] T

The Guangxi Key Laboratory of Environmental Exposomics and Entire Lifecycle Health, China

语种：

英文

关键词：

ferroptosis;Sillica nanoparticle (SiNP);Endothelial cell (EC);p38;Nrf2

期刊：

Frontiers in Public Health

ISSN：

2296-2565

年：

2023

卷：

页码：

1024130

DOI：

10.3389/fpubh.2023.1024130

基金类别：

This paper was funded by the National Natural Science Foundation of China (41877390) and the Foundation of State Key Laboratory of Organic Geochemistry, GIGCAS (SKLOG-202010).

机构署名：

本校为其他机构

院系归属：

公共卫生学院

摘要：

Introduction: Despite of growing evidence linking silica nanoparticles (SiNPs), one of the global-top-three-produced and -used nanoparticle (NP), to human health risks, there remain many knowledge gaps over the adverse effects of SiNPs exposure on cardiovascular system and the underlying molecular mechanisms. Methods: In this study, the ferroptotic effects of SiNPs (20 nm; 0, 25, 50, and 100 μg/mL) on human umbilical vein endothelial cells (HUVECs) and the possible molecular mechanism were studied with the corresponding biochemical and molecul...

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SiNPs induce ferroptosis in HUVECs through p38 inhibiting NrF2 pathway

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