SiNPs induce ferroptosis in HUVECs through p38 inhibiting NrF2 pathway

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成果类型：

期刊论文

作者：

Jiang, Xiaojun;Gao, Huiqian;Cao, Yunchang;Chen, Shuting;Huang, Fangfang;...

通讯作者：

Feng, S.

作者机构：

[Feng, Shaolong; Huang, Fangfang; Feng, Yashi; Zhang, Yuqi; Chen, Shuting; Gao, Huiqian; Jiang, Xiaojun] Guilin Med Univ, Sch Publ Hlth, Guangxi Key Lab Environm Expos & Entire Lifecycle, Guilin, Peoples R China.

[Feng, Shaolong; Chen, Shuting; Jiang, Xiaojun] Univ South China, Sch Publ Hlth, Hengyang, Peoples R China.

[Cao, Yunchang] Guilin Med Univ, Sch Intelligent Med & Biotechnol, Dept Mol Biol, Guilin, Peoples R China.

[Feng, Shaolong] Chinese Acad Sci, Guangzhou Inst Geochem, State Key Lab Organ Geochem, Guangzhou, Peoples R China.

通讯机构：

[Feng, S.] T

The Guangxi Key Laboratory of Environmental Exposomics and Entire Lifecycle Health, China

语种：

英文

关键词：

ferroptosis;Sillica nanoparticle (SiNP);Endothelial cell (EC);p38;Nrf2

期刊：

Frontiers in Public Health

ISSN：

2296-2565

年：

2023

卷：

页码：

1024130

DOI：

10.3389/fpubh.2023.1024130

基金类别：

This paper was funded by the National Natural Science Foundation of China (41877390) and the Foundation of State Key Laboratory of Organic Geochemistry, GIGCAS (SKLOG-202010).

机构署名：

本校为其他机构

院系归属：

公共卫生学院

摘要：

IntroductionDespite of growing evidence linking silica nanoparticles (SiNPs), one of the global-top-three-produced and -used nanoparticle (NP), to human health risks, there remain many knowledge gaps over the adverse effects of SiNPs exposure on cardiovascular system and the underlying molecular mechanisms.MethodsIn this study, the ferroptotic effects of SiNPs (20 nm; 0, 25, 50, and 100 μg/mL) on human umbilical vein endothelial cells (HUVECs) and the possible molecular mechanism were studied with the corresponding biochemical and molecular bi...

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SiNPs induce ferroptosis in HUVECs through p38 inhibiting NrF2 pathway

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