Insulin receptor binding motif tagged with IgG4 Fc (Yiminsu) works as an insulin sensitizer to activate Akt signaling in hepatocytes

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Wang, J.;Zou, T.;Yang, H. X.;Gong, Y. Z.;Xie, X. J.;...

通讯作者：

Liu, HY

作者机构：

[Yang, H. X.; Wang, J.] Univ South China, Key Lab Atherosclerol Hunan Prov, Inst Cardiovasc Res, Hengyang, Hunan, Peoples R China.

[Yang, H. X.; Wang, J.] Univ South China, Sch Publ Hlth, Hengyang, Hunan, Peoples R China.

[Zou, T.] Univ South China, Affiliated Hosp 1, Dept Cardiovasc Med, Hengyang, Hunan, Peoples R China.

[Gong, Y. Z.; Xie, X. J.; Liao, D. F.] Hunan Univ Chinese Med, State Key Lab Chinese Med Powder & Med Innovat Hu, Div Stem Cell Regulat & Applicat, Changsha, Hunan, Peoples R China.

[Liu, H. Y.; Liu, HY] Metammune LLC, Morrisville, NC 27560 USA.

通讯机构：

[Liu, HY ] M

Metammune LLC, Morrisville, NC 27560 USA.

语种：

英文

关键词：

IgG4 Fc;Insulin sensitizer;Type 2 diabetes;Yiminsu

期刊：

Genetics and Molecular Research

ISSN：

1676-5680

年：

2015

卷：

期：

页码：

8819-8828

DOI：

10.4238/2015.August.3.5

基金类别：

Technological Innovation Fund for Technology-based Small and Medium-sized Enterprises from the Ministry of Science and Technology of China [12C26213202441]; Science and Technology Bureau of Nanjing City; National Natural Science Foundation of China [81173047, 31371161]; Construct Program of the Pharmaceutical Science Key Discipline in Hunan Province; Human Provincial Education Department [14C0992]

机构署名：

本校为第一机构

院系归属：

医学院

药学与生物科学学院

公共卫生学院

摘要：

Insulin resistance is a key feature of obesity and type 2 diabetes mellitus (T2DM). Interaction of insulin with the insulin receptor (IR) leads to both its auto-phosphorylation and phosphorylation of tyrosine residues on the IR substrate (IRS) proteins, initiating the activation of intracellular signaling cascades. The metabolic effects of IRS are known to be mediated through pathways involving phosphatidyl-inositol 3-kinase (PI-3K), which result in the activation of Akt signaling. The C-terminal region of the IR ectodomain is required to facilitate the conformational changes that are required...

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Insulin receptor binding motif tagged with IgG4 Fc (Yiminsu) works as an insulin sensitizer to activate Akt signaling in hepatocytes

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