ERK1/2 and the Bcl-2 Family Proteins Mcl-1, tBid, and Bim Are Involved in Inhibition of Apoptosis During Persistent Chlamydia psittaci Infection

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Li, Li;Wang, Chuan;Wen, Yating;Hu, Yuming;Xie, Yafeng;...

通讯作者：

Wu, Yimou

作者机构：

[Wu, Yimou; Li, Li; Xie, Yafeng; Liu, Wei; Liu, Liangzhuan; Liang, Mingxing; Wen, Yating; Wang, Chuan; Xu, Man] Univ South China, Med Coll, Inst Pathogen Biol, Hunan Prov Key Lab Special Pathogens Prevent & Co, Hengyang, Peoples R China.

[Wu, Yimou; Li, Li; Xie, Yafeng; Liu, Wei; Liu, Liangzhuan; Liang, Mingxing; Wen, Yating; Wang, Chuan; Xu, Man] Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, Hengyang 421001, Peoples R China.

通讯机构：

[Wu, Yimou] U

[Wu, Yimou] H

Univ South China, Med Coll, Inst Pathogen Biol, Hunan Prov Key Lab Special Pathogens Prevent & Co, Hengyang, Peoples R China.

Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, Hengyang 421001, Peoples R China.

语种：

英文

关键词：

Bcl-2 family proteins;Chlamydia psittaci;IFN-gamma;apoptosis;persistent infection

期刊：

Inflammation

ISSN：

0360-3997

年：

2018

卷：

期：

页码：

1372-1383

DOI：

10.1007/s10753-018-0785-8

基金类别：

Funding This work was supported by the National Natural Science Foundation of China (grant nos. 31270218 and 31300156), the Special Foundation of Hunan Provincial Science and Technology Department (grant no. 2013TT1003), and the Hunan Provincial Key Laboratory for Special Pathogens Prevention and Control Foundation (grant nos. 2014-5 and 2012-312).

机构署名：

本校为第一且通讯机构

院系归属：

医学院

摘要：

Chlamydia psittaci is an obligate intracellular pathogen that can cause zoonosis. Persistent C. psittaci infection can inhibit apoptosis in host cells, thus extending their survival and enabling them to complete their growth cycle. In this study, the antiapoptotic effects of persistent C. psittaci infection, induced by treatment with IFN-γ, were found to be associated with both the death receptor and the mitochondrial pathways of apoptosis. These effects were mediated by Bcl-2 family members, as evidenced by the decreased expression of proapop...

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ERK1/2 and the Bcl-2 Family Proteins Mcl-1, tBid, and Bim Are Involved in Inhibition of Apoptosis During Persistent Chlamydia psittaci Infection

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