Aberrant expression of KDM1A inhibits ferroptosis of lung cancer cells through up-regulating c-Myc

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成果类型：

期刊论文

作者：

Lu, Can;Cai, Yuan;Liu, Wei;Peng, Bi;Liang, Qiuju;...

通讯作者：

Yan, Yuanliang<&wdkj&>Liang, Desheng<&wdkj&>Xu, Zhijie

作者机构：

[Peng, Bi; Cai, Yuan; Xu, Zhijie; Lu, Can] Cent South Univ, Xiangya Hosp, Dept Pathol, Changsha, Peoples R China.

[Liang, Desheng; Lu, Can] Cent South Univ, Sch Life Sci, Ctr Med Genet, Changsha, Peoples R China.

[Liang, Desheng; Lu, Can] Cent South Univ, Sch Life Sci, Hunan Key Lab Med Genet, Changsha, Peoples R China.

[Liu, Wei] Univ South China, Dept Orthoped Surg, Hosp 2, Hengyang, Peoples R China.

[Yan, Yuanliang; Liang, Qiuju] Cent South Univ, Xiangya Hosp, Dept Pharm, Changsha, Peoples R China.

通讯机构：

[Yan, Yuanliang; Xu, Zhijie] D

[Liang, Desheng] C

Department of Pathology, Xiangya Hospital, Central South University, Changsha, China<&wdkj&>National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China<&wdkj&>Center for Medical Genetics & Hunan Key Laboratory of Medical Genetics, School of Life Sciences, Central South University, Changsha, China<&wdkj&>Department of Pharmacy, Xiangya Hospital, Central South University, Changsha, China

语种：

英文

期刊：

Scientific Reports

ISSN：

2045-2322

年：

2022

卷：

期：

DOI：

10.1038/s41598-022-23699-4

基金类别：

This study is supported by Grants from the Science and Technology Innovation Program of Hunan Province (2022RC1210).

机构署名：

本校为其他机构

摘要：

Ferroptosis is a cell death process caused by metabolic dysfunction with the feature of aberrant iron accumulation. Emerging studies have identified that ferroptosis is an important biological function involving in the tumorigenesis, and targeting ferroptosis could provide promising therapeutic targets for lung cancer. However, such therapeutic strategies show limited therapeutic effect owing to drug resistance and other unknown underlying mechanisms. In this study, lysine-specific demethylase 1 (LSD1/KDM1A) was found to be significantly upregulated in lung cancer cells and tissues. The patien...

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Aberrant expression of KDM1A inhibits ferroptosis of lung cancer cells through up-regulating c-Myc

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