Therapeutic Strategies Targeting Mitochondrial Dysfunction in Sepsis-induced Cardiomyopathy

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成果类型：

期刊论文

作者：

Salami, Oluwabukunmi Modupe;Habimana, Olive;Peng, Jin-Fu;Yi, Guang-Hui

通讯作者：

Guang-Hui Yi

作者机构：

[Salami, Oluwabukunmi Modupe; Habimana, Olive] Univ South China, Int Coll, 28 W Changsheng Rd, Hengyang 421001, Hunan, Peoples R China.

[Yi, Guang-Hui; Peng, Jin-Fu] Univ South China, Hengyang Med Sch, Inst Cardiovasc Dis, Key Lab Arteriosclerol Hunan Prov, 28 W Changsheng Rd, Hengyang 421001, Hunan, Peoples R China.

[Yi, Guang-Hui; Peng, Jin-Fu] Univ South China, Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, Inst Pharm & Pharmacol, 28 W Changsheng Rd, Hengyang 421001, Hunan, Peoples R China.

通讯机构：

[Guang-Hui Yi] I

Institute of Cardiovascular Disease, Key Laboratory for Arteriosclerology of Hunan Province, Hengyang Medical School, University of South China, Hengyang, China<&wdkj&>Institute of Pharmacy and Pharmacology, Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, University of South China, Hengyang, China

语种：

英文

关键词：

Sepsis;Mitochondrial dysfunction;Cardiomyopathy;Drugs;Preclinical study

期刊：

Cardiovascular Drugs and Therapy

ISSN：

0920-3206

年：

2024

卷：

期：

页码：

163-180

DOI：

10.1007/s10557-022-07354-8

基金类别：

This work was supported by the National Natural Sciences Foundation of China (No. 81770490), the Planned Science and Technology Project of Hunan Province, China (No.2020JJ4535), and the Key Laboratory for Arteriosclerology of Hunan Province (Basic Medicine Sciences in University of South China).

机构署名：

本校为第一机构

院系归属：

医学院

药学与生物科学学院

摘要：

Sepsis is an increasingly worldwide problem; it is currently regarded as a complex life-threatening dysfunction of one or more organs as a result of dysregulated host immune response to infections. The heart is one of the most affected organs, as roughly 10% to 70% of sepsis cases are estimated to turn into sepsis-induced cardiomyopathy (SIC). SIC can be defined as a reversible myocardial dysfunction characterized by dilated ventricles, impaired contractility, and decreased ejection fraction. Mitochondria play a critical role in the normal func...

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