WAVE1 regulates P-glycoprotein expression via Ezrin in leukemia cells

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成果类型：

期刊论文

作者：

Yang, Ming-Hua;Zhao, Ming-Yi;Wang, Zhuo;Kang, Rui;He, Yu-Lei;...

通讯作者：

Cao, Li-Zhi

作者机构：

[Zhan, Cai-Xia; Liu, Li-Ying; Cao, Li-Zhi; Yang, Ming-Hua; Zhao, Ming-Yi; Wang, Zhuo; Kang, Rui; Yang, Liang-Chun] Cent S Univ, Xiangya Hosp, Dept Pediat, Changsha 410008, Hunan, Peoples R China.

[He, Yu-Lei] Childrens Hosp Chengdou, Chengdu, Sichuan Prov, Peoples R China.

[Yin, Xiao-Cheng] Nanhua Univ, Affiliated Hosp 1, Dept Pediat, Hengyang, Hunan, Peoples R China.

[Kang, Rui; Tang, Dao-Lin] Univ Pittsburgh, Inst Canc, Hillman Canc Ctr, Pittsburgh, PA USA.

[Wu, Xiu-Shan] Hunan Normal Univ, Coll Life Sci, Changsha, Hunan, Peoples R China.

通讯机构：

[Cao, Li-Zhi] C

Cent S Univ, Xiangya Hosp, Dept Pediat, Changsha 410008, Hunan, Peoples R China.

语种：

英文

关键词：

WAVE1;drug resistance;Ezrin;P-glycoprotein

期刊：

Leukemia & Lymphoma

ISSN：

1042-8194

年：

2011

卷：

期：

页码：

298-309

DOI：

10.3109/10428194.2010.538776

基金类别：

National Natural Sciences Foundation of ChinaNational Natural Science Foundation of China (NSFC) [30571982, 30772353, 30973234, 30500485]; Doctoral Program of Higher Education of ChinaSpecialized Research Fund for the Doctoral Program of Higher Education (SRFDP) [20070533042]; University of PittsburghUniversity of Pittsburgh

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本校为其他机构

摘要：

For children with acute myeloblastic leukemia (AML), multidrug resistance (MDR) reduces treatment effectiveness, and often leads to poor patient survival. While a number of factors have been described that affect MDR, the mechanisms underlying this effect remain unclear. In this study, the role of WAVE1 in MDR was investigated. Among 62 children with AML, high levels of WAVE1 were associated with poor patient outcomes. Proteomic techniques were used to identify novel WAVE1-interacting proteins from leukemia cells, one of which was the cytoskeleton regulator Ezrin. In leukemia cells, WAVE1 co-l...

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WAVE1 regulates P-glycoprotein expression via Ezrin in leukemia cells

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