Irradiation Activates MZF1 to Inhibit miR-541-5p Expression and Promote Epithelial-Mesenchymal Transition (EMT) in Radiation-Induced Pulmonary Fibrosis (RIPF) by Upregulating Slug

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Liang, Xinxin;Yan, Ziyan;Wang, Ping;Liu, Yuhao;Ao, Xingkun;...

通讯作者：

Gu, Yongqing;Zhou, Pingkun

作者机构：

[Gu, Yongqing; Liang, Xinxin; Ao, Xingkun] Univ South China, Hengyang Med Coll, Hengyang 421001, Peoples R China.

[Zhou, Pingkun; Gu, YQ; Liu, Xiaochang; Xie, Dafei; Gu, Yongqing; Wang, Ping; Zhu, Maoxiang; Liang, Xinxin; Yan, Ziyan; Wang, Duo; Liu, Yuhao; Gao, Shanshan] Beijing Inst Radiat Med, Beijing Key Lab Radiobiol, Beijing 100850, Peoples R China.

[Liu, Zheng] Univ South China, Sch Publ Hlth, Hengyang 421001, Peoples R China.

通讯机构：

[Gu, Yongqing] U

[Zhou, PK; Gu, YQ] B

Univ South China, Hengyang Med Coll, Hengyang 421001, Peoples R China.

Beijing Inst Radiat Med, Beijing Key Lab Radiobiol, Beijing 100850, Peoples R China.

语种：

英文

关键词：

miR-541-5p;EMT;slug;MZF1;radiation-induced pulmonary fibrosis

期刊：

International Journal of Molecular Sciences

年：

2021

卷：

期：

DOI：

10.3390/ijms222111309

基金类别：

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81773359, 82073488, 31870847and 31470827]

机构署名：

本校为第一且通讯机构

院系归属：

公共卫生学院

摘要：

Understanding miRNAs regulatory roles in epithelial-mesenchymal transition (EMT) would help establish new avenues for further uncovering the mechanisms underlying radiation-induced pulmonary fibrosis (RIPF) and identifying preventative and therapeutic targets. Here, we demonstrated that miR-541-5p repression by Myeloid Zinc Finger 1 (MZF1) promotes radiation-induced EMT and RIPF. Irradiation could decrease miR-541-5p expression in vitro and in vivo and inversely correlated to RIPF development. Ectopic miR-541-5p expression suppressed radiation-induced-EMT in vitro and in vivo. Knockdown of Slu...

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Irradiation Activates MZF1 to Inhibit miR-541-5p Expression and Promote Epithelial-Mesenchymal Transition (EMT) in Radiation-Induced Pulmonary Fibrosis (RIPF) by Upregulating Slug

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