This study was supported by the Excellent Youth Foundation of Educational Commission of Hunan Province, China [grant number: 20b495], the Guidance Projects of Science and Technology Department of Hengyang, Hunan Province, China [grant number: s2018F9C31022 [20b495]; Excellent Youth Foundation of Educational Commission of Hunan Province, China [s2018F9C31022244, 2019124]; Guidance Projects of Science and Technology Department of Hengyang, Hunan Province, China [B202314057822]; Research Project of Hunan Provincial Health Commission