Quantitative Proteomic Analysis of Differential Proteins in the Stroma of Nasopharyngeal Carcinoma and Normal Nasopharyngeal Epithelial Tissue

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成果类型：

期刊论文

作者：

Li, Mei-Xiang;Xiao, Zhi-Qiang;Liu, Ying-Fu;Chen, Yong-Heng;Li, Cui;...

通讯作者：

Chen, Zhu-Chu

作者机构：

[Duan, Chao-Jun; Yao, Hui-Xin; Li, Cui; Xiao, Zhi-Qiang; Li, Mei-Xiang; Yi, Hong; Li, Mao-Yu; Zhang, Peng-Fei; Peng, Fang; Chen, Zhu-Chu; Liu, Ying-Fu] Cent S Univ, Xiangya Hosp, Key Lab Canc Proteom, Chinese Minist Hlth, Changsha 410008, Hunan, Peoples R China.

[Yao, Hui-Xin; Li, Feng; Li, Mei-Xiang; Chen, Zhu-Chu; Liu, Ying-Fu] Cent S Univ, Xiangya Sch Med, Canc Res Inst, Changsha 410078, Hunan, Peoples R China.

[Li, Mei-Xiang] Univ S China, Dept Histol & Embryol, Hengyang 421001, Hunan, Peoples R China.

[Chen, Yong-Heng] Univ So Calif, Los Angeles, CA USA.

[Chen, Zhu-Chu] Cent S Univ, Xiangya Hosp, Key Lab Canc Proteom, Chinese Minist Hlth, 87 Xiangya Rd, Changsha 410008, Hunan, Peoples R China.

通讯机构：

[Chen, Zhu-Chu] C

Cent S Univ, Xiangya Hosp, Key Lab Canc Proteom, Chinese Minist Hlth, 87 Xiangya Rd, Changsha 410008, Hunan, Peoples R China.

语种：

英文

关键词：

nasopharyngeal carcinoma;stroma;laser capture microdissection;2‐D DIGE;carcinogenesis

期刊：

JOURNAL OF CELLULAR BIOCHEMISTRY

ISSN：

0730-2312

年：

2009

卷：

106

期：

页码：

570-579

DOI：

10.1002/jcb.22028

基金类别：

National Key Basic Research Program of China; Ministry of Education of China; Hibiscus Scholars of Hunan Province, China; Science and Technology Committee of Hunan, China; Public Health Bureau of Hunan Province, China; National Natural Sciences Foundation of China [2001CB510207, 2002-48, 2007-362, 04XK1001-1, 05SK1004-1, Z02-04, 30500558, 30670990, 2007-70]

机构署名：

本校为其他机构

院系归属：

医学院

摘要：

Abstract The importance of stromal cells and the factors that they expressed during cancer initiation and progression have been highlighted by recent literature. To identify the stromal proteins involved in nasopharyngeal carcinoma (NPC) carcinogenesis, we assessed differences in protein expression of the stroma from NPC and normal nasopharyngeal epithelium tissues (NNET) using a quantitative proteomic approach combined with laser capture microdissection (LCM). LCM was performed to purify stromal cells from the NPC and NNET, respectively. The d...

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Quantitative Proteomic Analysis of Differential Proteins in the Stroma of Nasopharyngeal Carcinoma and Normal Nasopharyngeal Epithelial Tissue

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