期刊论文

Tang, Zhi-Han

英文

Atherosclerosis

0021-9150

2018

268

170-176

10.1016/j.atherosclerosis.2017.11.033

This work was supported by the Fellowship Award of International atherosclerosis society (2017) , the grants from the Educational Department of Hunan Province Fund for Distinguished Young Scholars ( 16B228 ), the Hunan Province Postgraduate Research and Innovation Project ( CX2017B549 ), the Undergraduate Training Programs for Innovation and Entrepreneurship ( 20161055500 , 2016-283-309 ), and the Construct Program of the Basic Medicine Key Discipline in Hunan Province . This work was supported by the Fellowship Award of International atherosclerosis society (2017), the grants from the Educational Department of Hunan Province Fund for Distinguished Young Scholars (16B228), the Hunan Province Postgraduate Research and Innovation Project (CX2017B549), the Undergraduate Training Programs for Innovation and Entrepreneurship (20161055500, 2016-283-309), and the Construct Program of the Basic Medicine Key Discipline in Hunan Province.

本校为第一且通讯机构

Transmembrane 6 superfamily 2 (TM6SF2), a gene identified at the locus 19p12, has been recognized to regulate plasma lipids. Here, we provide an overview of the roles of TM6SF2 as a novel target for plasma lipid regulation. We first review the association of TM6SF2 variant with plasma lipid traits, cardiovascular disease (CVD) and non-alcoholic fatty liver disease (NAFLD). Then, we present an overview about the in vivo validation of TM6SF2 as a regulator of plasma lipid levels using mice, with overexpression or knockdown/knockout of TM6SF2. The...