Neuropathy Target Esterase Is Degraded by the Ubiquitin-Proteasome Pathway with ARA54 as the Ubiquitin Ligase

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成果类型：

期刊论文

作者：

Long, Ding-Xin;Wang, Pan;Sun, Ying-Jian;Chen, Rui;Wu, Yi-Jun*

通讯作者：

Wu, Yi-Jun

作者机构：

[Sun, Ying-Jian; Wang, Pan; Wu, Yi-Jun; Long, Ding-Xin; Chen, Rui] Chinese Acad Sci, Inst Zool, State Key Lab Integrated Management Pest Insects, Lab Mol Toxicol, Beijing 100101, Peoples R China.

[Long, Ding-Xin] Univ South China, Sch Publ Hlth, Hengyang 421001, Peoples R China.

[Sun, Ying-Jian] Beijing Agr Coll, Dept Vet Med & Anim Sci, Beijing 102206, Peoples R China.

[Wu, Yi-Jun] Chinese Acad Sci, Inst Zool, 1-5 Beichenxilu Rd, Beijing 100101, Peoples R China.

通讯机构：

[Wu, Yi-Jun] C

Chinese Acad Sci, Inst Zool, 1-5 Beichenxilu Rd, Beijing 100101, Peoples R China.

语种：

英文

期刊：

BIOCHEMISTRY

ISSN：

0006-2960

年：

2015

卷：

期：

页码：

7385-7392

DOI：

10.1021/acs.biochem.5b00879

基金类别：

CAS Strategic Priority Research Program [XDB14040203]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [31301927, 31472007, 81172712]; National Basic Research Program of ChinaNational Basic Research Program of China [2012CB114100]

机构署名：

本校为其他机构

院系归属：

公共卫生学院

摘要：

Neuropathy target esterase (NTE) is an endoplasmic reticulum membrane-associated phospholipase B, which is essential for embryonic and nervous system development. However, the regulation of NTE at the protein level had not been thoroughly investigated. Our previous study showed that NTE was degraded not only by the macroautophagy-lysosome pathway but also by the ubiquitin-proteasome pathway. Here we further reveal that androgen receptor-associated protein 54 (ARA54) regulated the ubiquitin-proteasome degradation of NTE. We find that deletion of...

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Neuropathy Target Esterase Is Degraded by the Ubiquitin-Proteasome Pathway with ARA54 as the Ubiquitin Ligase

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