LncRNA LUCRC Regulates Colorectal Cancer Cell Growth and Tumorigenesis by Targeting Endoplasmic Reticulum Stress Response

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成果类型：

期刊论文

作者：

Tang, Guo-Hui;Chen, Xue;Ding, Jian-Cheng;Du, Jun;Lin, Xiao-Ting;...

通讯作者：

He, Xiu-Sheng;Liu, Wen;Ye, Feng

作者机构：

[He, Xiu-Sheng; Tang, Guo-Hui] Univ South China, Hunan Prov Key Lab Canc Cellular & Mol Pathol, Hengyang, Peoples R China.

[He, Xiu-Sheng; Tang, Guo-Hui] Univ South China, Canc Res Inst, Hengyang Med Coll, Hengyang, Peoples R China.

[Tang, Guo-Hui] Univ South China, Dept Anus & Bowels, Affiliated Nanhua Hosp, Hengyang, Peoples R China.

[Du, Jun; Ding, Jian-Cheng; Liu, Wen; Chen, Xue] Xiamen Univ, Fujian Prov Key Lab Innovat Drug Target Res, Sch Pharmaceut Sci, Xiamen, Peoples R China.

[Xia, Lu; Lian, Jia-Bian; Lin, Xiao-Ting; Ye, Feng] Xiamen Univ, Dept Med Oncol, Affiliated Hosp 1, Xiamen, Peoples R China.

通讯机构：

[He, Xiu-Sheng] U

[Liu, Wen; Ye, Feng] X

Univ South China, Hunan Prov Key Lab Canc Cellular & Mol Pathol, Hengyang, Peoples R China.

Univ South China, Canc Res Inst, Hengyang Med Coll, Hengyang, Peoples R China.

Xiamen Univ, Fujian Prov Key Lab Innovat Drug Target Res, Sch Pharmaceut Sci, Xiamen, Peoples R China.

语种：

英文

关键词：

cell growth;colorectal cancer;long non-coding RNA;therapeutic target;unfolded protein response

期刊：

Frontiers in Genetics

ISSN：

1664-8021

年：

2020

卷：

页码：

501407

DOI：

10.3389/fgene.2019.01409

基金类别：

This work was supported by National Natural Science Foundation of China (81761128015, 81861130370, 31871319, and 91953114), Fujian Province Health Education Joint Research Project (WKJ2016-2-09), Xiamen Science and Technology Project (2017S0091), Xiamen Science and Technology major projects (3502Z20171001-20170302), and the Fundamental Research Funds for the Central University (2013121036 and 20720190145) to WL. Hunan Province Clinical Medical Technology Innovation Guide Program to G-HT.

机构署名：

本校为第一且通讯机构

院系归属：

医学院

摘要：

Colorectal cancer (CRC) is the second most common cause of cancer-related death worldwide, and is well known for its strong invasiveness, rapid recurrence, and poor prognosis. Long non-coding RNAs (lncRNAs) have been shown to be involved in the development of various types of cancers, including colorectal cancer. Here, through transcriptomic analysis and functional screening, we reported that lncRNA LUCRC (LncRNA Upregulated in Colorectal Cancer) is highly expressed in colorectal tumor samples and is required for colorectal cancer cell proliferation, migration, and invasion in cultured cells a...

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LncRNA LUCRC Regulates Colorectal Cancer Cell Growth and Tumorigenesis by Targeting Endoplasmic Reticulum Stress Response

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