Lipoprotein lipase （LPL） hydrolyzes plasma triglyceride-rich lipoproteins into free fatty acids （FFA） to provide energy for cardiac tissue. During diabetes, cardiac energy supply is insufficient due to defected utilization of glucose. As a compensation of cardiac energy supply, FFAs are released through the hydrolysis of very low density lipoprotein （VLDL） and chylomicrons （CM） due to activation of LPL activity. In diabetic patients, activated LPL activity and elevated FFAs result in the intracellular accumu- lation of reactive oxygen s...
