Apolipoprotein AI ( apoA-I ) is the major protein component of high-density lipoprotein ( HDL) ,and apoA -I can stabilize the structure of HDL .Whereas the amphipathic αh-elix is the structur -al motif for apoA-I to complete the corresponding functionality .In the lipid-free state, the N-terminal of apoA-I molecule is a dynamic four-helix bundle structure , most amino acid residues of the C-terminal do-main is the formation of a disordered structure , which is the initial domain that mediates bingding to phos-pholipid surface .Two molecules of...
