MMP-12 as a potential biomarker to forecast ischemic stroke in obese patients

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成果类型：

期刊论文

作者：

Wang, Chu-yao;Zhang, Cai-ping;Li, Bo-Jie;Jiang, Su-su;He, Wei-he;...

通讯作者：

Long, Shi-yin;Tian, Y

作者机构：

[Wang, Chu-yao; Long, Shi-yin; Zhang, Cai-ping; Li, Bo-Jie; Jiang, Su-su] Univ South China, Med Coll, Dept Biochem & Mol Biol, Hengyang 421001, Hunan, Peoples R China.

[Tian, Ying] Univ South China, Affiliated Nanhua Hosp, 336 S Dongfeng Rd, Hengyang 421001, Hunan, Peoples R China.

[He, Wei-he] Hunan Univ Chinese Med, Dept Pharmacol, Coll Pharm, 300 Xueshi Rd, Changsha 410208, Hunan, Peoples R China.

[Long, SY; Tian, Ying] Univ South China, Dept Biochem & Mol Biol, 28 W Changsheng Rd, Hengyang 421001, Hunan, Peoples R China.

通讯机构：

[Long, SY; Tian, Y ] U

Univ South China, Dept Biochem & Mol Biol, 28 W Changsheng Rd, Hengyang 421001, Hunan, Peoples R China.

语种：

英文

关键词：

biological marker;macrophage elastase;biological marker;macrophage elastase;MMP12 protein, human;thrombin;Article;brain ischemia;forecasting;human;nonhuman;obesity;animal;apoptosis;brain ischemia;complication;incidence;inflammation;longevity;metabolism;obesity;pathophysiology;Animals;Apoptosis;Biomarkers;Brain Ischemia;Humans;Incidence;Inflammation;Ischemic Stroke;Longevity;Matrix Metalloproteinase 12;Obesity;Thrombin

期刊：

Medical Hypotheses

ISSN：

0306-9877

年：

2020

卷：

136

页码：

109524

DOI：

10.1016/j.mehy.2019.109524

基金类别：

This work was supported by the National Nature Science Fund of China (31871169, 81600291), the Nature Science Fund of Hunan Province (2018JJ2348, 2018JJ2346, and 2018JJ2300), supported by Hunan Provincial Innovation Foundation for Postgraduate (CX2018B625), Hunan Provincial Department of Education Excellent Youth Project (16B272). This work was supported by the National Nature Science Fund of China ( 31871169 , 81600291 ), the Nature Science Fund of Hunan Province ( 2018JJ2348 , 2018JJ2346 , and 2018JJ2300 ), supported by Hunan Provincial Innovation Foundation for Postgraduate ( CX2018B625 ), Hunan Provincial Department of Education Excellent Youth Project ( 16B272 ).

机构署名：

本校为第一且通讯机构

院系归属：

医学院

药学与生物科学学院

摘要：

Human health is threatened by obesity which causes the increasing incidence of various diseases, especially stroke. Ischemic stroke (IS) is mostly caused by the rupture of arterial plaque, whose instability is positively associated with matrix metalloproteinases (MMPs) that degrades extracellular matrix components. Studies have shown that matrix metalloproteinase-12 (MMP-12) may be involved in the pathogenesis of IS. Because of the higher incidence of stroke in obese patients than that in normal weight people, it is urgent for obesity to foreca...

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MMP-12 as a potential biomarker to forecast ischemic stroke in obese patients

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