PD-L1 and miR-34a are Prognostic Factors for Primary Gastric Diffuse Large B-Cell Lymphoma Patients Treated with R-CHOP

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成果类型：

期刊论文

作者：

Wang, Jinfeng;Shang, Song;Li, Junjun;Deng, Hongyu;Ouyang, Linda;...

通讯作者：

Li, Yajun;Zuo, Chaohui

作者机构：

[Shang, Song; Deng, Hongyu; Li, Junjun; Li, Yajun; Wang, Jinfeng; Ouyang, Linda; Zuo, Chaohui] Cent South Univ, Dept Gastroduodenal & Pancreat Surg, Translat Med Res Ctr Liver Canc, Xiangya Med Sch,Lab Digest Oncol,Affiliated Canc, Changsha, Peoples R China.

[Shang, Song; Deng, Hongyu; Li, Junjun; Li, Yajun; Wang, Jinfeng; Ouyang, Linda; Zuo, Chaohui] Cent South Univ, Hunan Canc Hosp, Changsha, Peoples R China.

[Xie, Hailong] Univ South China, Canc Res Inst, Grad Sch, Hengyang, Peoples R China.

[Zhu, Haizhen] Hunan Univ, State Key Lab Chemo Biosensing & Chemometr, Coll Biol, Inst Pathogen Biol & Immunol, Changsha, Peoples R China.

[Li, Yajun] Cent South Univ, Dept Gastroduodenal & Pancreat Surg, Lab Digest Oncol, Affiliated Tumor Hosp,Xiangya Med Sch, Changsha, Peoples R China.

通讯机构：

[Li, Yajun; Zuo, Chaohui] C

Cent South Univ, Hunan Canc Hosp, Changsha, Peoples R China.

Cent South Univ, Hunan Univ Hunan Prov Tumor Hosp Joint Ctr Liver, Dept Gastroduodenal & Pancreat Surg, Lab Digest Oncol,Affiliated Tumor Hosp,Xiangya Me, Changsha, Peoples R China.

Cent South Univ, Hunan Univ Hunan Prov Tumor Hosp Joint Ctr Liver, Hunan Canc Hosp, Changsha, Peoples R China.

Cent South Univ, Dept Gastroduodenal & Pancreat Surg, Lab Digest Oncol, Affiliated Tumor Hosp,Xiangya Med Sch, Changsha, Peoples R China.

语种：

英文

关键词：

GDLBCL;R-CHOP;PD-L1;miR-34a;tumor immunotherapy

期刊：

CANCER MANAGEMENT AND RESEARCH

ISSN：

1179-1322

年：

2020

卷：

页码：

4999-5008

DOI：

10.2147/CMAR.S247874

基金类别：

This study was supported by Industry Research Project from the Development and Reform Commission of Hunan Province (2015-99, to Chaohui Zuo), and Key Research Project from the Hunan Provincial Science and Technology Department (2017k2130, to Chaohui Zuo). We thank Chen Liu for assistance with the writing of the manuscript.

机构署名：

本校为其他机构

院系归属：

医学院

摘要：

INTRODUCTION: Primary gastric diffuse large B-cell lymphoma (GDLBCL) is a heterogeneous disease in clinicopathological features and prognosis. Programmed death ligand-1 (PD-L1) and microRNA-34a (miR-34a) play crucial roles in GDLBCL progress. The purpose of this research is to explore the clinical significance of PD-L1 and miR-34a expression in GDLBCL. PATIENTS AND METHODS: The expressions of PD-L1 and miR-34a were examined by IHC and qRT-PCR in 109 patients who were diagnosed with GDLBCL and were treated with rituximab plus cyclophosphamide, doxorubicin, prednisone vincristine and prednisone ...

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PD-L1 and miR-34a are Prognostic Factors for Primary Gastric Diffuse Large B-Cell Lymphoma Patients Treated with R-CHOP

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