Itaconate inhibits corticosterone-induced necroptosis and neuroinflammation via up-regulating menin in HT22 cells

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Liang, Jin-Yu;Gao, Shan;Jiang, Jia-Mei;Zhang, Pin;Zou, Wei;...

通讯作者：

Tang, Xiao-Qing;Tang, YY;Tang, XQ

作者机构：

[Gao, Shan; Tang, Yi-Yun; Liang, Jin-Yu; Tang, Xiao-Qing; Tang, XQ; Jiang, Jia-Mei] Univ South China, Inst Neurosci, Hengyang Med Sch, 28 W Changsheng Rd, Hengyang 421001, Hunan, Peoples R China.

[Zou, Wei; Zhang, Pin] Univ South China, Affiliated Nanhua Hosp, Dept Neurol, 336 S Dongfeng Rd, Hengyang 421002, Hunan, Peoples R China.

[Tang, Xiao-Qing; Tang, XQ] Univ South China, Affiliated Hosp 2, Dept Neurol, Hengyang 421001, Hunan, Peoples R China.

通讯机构：

[Tang, YY ; Tang, XQ; Tang, XQ ] U

Univ South China, Inst Neurosci, Hengyang Med Sch, 28 W Changsheng Rd, Hengyang 421001, Hunan, Peoples R China.

Univ South China, Affiliated Hosp 2, Dept Neurol, Hengyang 421001, Hunan, Peoples R China.

语种：

英文

关键词：

Itaconate;Menin;Corticosterone;Necroptosis;Neuroinflammation

期刊：

Journal of Physiology and Biochemistry

ISSN：

1138-7548

年：

2024

页码：

1-13

DOI：

10.1007/s13105-024-01012-3

基金类别：

National Natural Science Foundation of China [81971267]; Project of Hunan Provincial Department of Education [21B0429]

机构署名：

本校为第一且通讯机构

院系归属：

医学院

摘要：

Corticosterone (CORT) damages hippocampal neurons as well as induces neuroinflammation. The tricarboxylic acid cycle metabolite itaconate has an anti-inflammatory role. Necroptosis is a form of programmed cell death, also known as inflammatory cell death. Menin is a multifunctional scaffold protein, which deficiency aggravates neuroinflammation. In this study, we explored whether itaconate inhibits CORT-induced neuroinflammation as well as necroptosis and further investigated the mediatory role of Menin in this protective effect of itaconate by...

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Itaconate inhibits corticosterone-induced necroptosis and neuroinflammation via up-regulating menin in HT22 cells

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