Apatinib Inhibits Stem Properties and Malignant Biological Behaviors of Breast Cancer Stem Cells by Blocking Wnt/β-catenin Signal Pathway through Down-regulating LncRNA ROR

首页 > 成果 > 详情

认领

导出

Link by DOI

反馈

作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Jiang, Baohong;Zhu, Hongbo;Tang, Liting;Gao, Ting;Zhou, Yu;...

通讯作者：

Li, Y.

作者机构：

[Jiang, Baohong] Univ South China, Affiliated Hosp 1, Hengyang Med Sch, Dept Pharm, Hengyang, Hunan, Peoples R China.

[Gong, Fuqiang; Tan, Yeru; Zhu, Hongbo; Zhou, Yu; Li, Yuehua; Tang, Liting; Gao, Ting; Xie, Liming; Wu, Xiaoping] Univ South China, Affiliated Hosp 1, Hengyang Med Sch, Dept Med Oncol, 69 Chuanshan Rd, Hengyang 421001, Hunan, Peoples R China.

通讯机构：

[Li, Y.] D

Department of Medical Oncology, The First Affiliated Hospital, Hengyang Medical School, University of South China, No. 69, Chuanshan Road, Hunan Province, Hengyang, China

语种：

英文

关键词：

Apatinib;BCSCs;LncRNA ROR;Wnt/β-catenin;stem property;EMT.

期刊：

ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY

ISSN：

1871-5206

年：

2022

卷：

期：

页码：

1723-1734

DOI：

10.2174/1871520621666210412103849

基金类别：

This work was financially supported by the National Natural Science Foundation of China (NO.81902707 to YHL), the Hunan Provincial Natural Science Foundation (NO.2018JJ6092 to BHJ and 2019JJ50537 to YHL), the Health and Family Planning Commission of Hunan Province (B2019120 to BHJ, C2019113 to XPW, C2019114 to YHL), the Science and Technology Project of Hengyang (NO. S2018F9031021272 to YHL).

机构署名：

本校为第一机构

院系归属：

医学院

药学与生物科学学院

摘要：

Background: Cancer stem cells could influence tumor recurrence and metastasis. Objective: To develop a new effective treatment modality targeting breast cancer stem cells (BCSCs) and to explore the role of Apatinib in BCSCs. Methods: BCSCs were isolated from MDA-MB-231 cells by the immune magnetic beads method. BCSCs were treated with Apatinib, lentiviral plasmids (lncRNA ROR), and iCRT-3 (Wnt pathway inhibitors). Viability, colony numbers, sphere numbers, apoptosis, migration, invasion of BCSCs were detected by MTT, colony formation, tumorsphe...

反馈

产权有误：本人成果被他人认领

数据有误：数据基本信息有误

归属有误：成果的院系归属、机构署名归属有误

其他原因：

验证码：

看不清楚，换一个

确定

取消

成果认领

标题：

用户	作者	通讯作者	--
	请选择	请选择	--

确定

取消

Apatinib Inhibits Stem Properties and Malignant Biological Behaviors of Breast Cancer Stem Cells by Blocking Wnt/β-catenin Signal Pathway through Down-regulating LncRNA ROR

反馈

成果认领

提示

该栏目需要登录且有访问权限才可以访问