期刊论文、会议论文

Relationship among COX-2, VEGF, MVD and invasion and metastasis of gastric carcinoma

中文

中国内镜杂志

1007-1989

2005

11

5

471-473

中国医师协会内镜医师分会成立大会、中国第十四届内镜医学学术大会、《中国内镜杂志》创刊十周年学术讨论会、恩德思奖（Endoscopics Award）颁奖大会

2005-06

中国北京

10.3969/j.issn.1007-1989.2005.05.009

本校为第一机构

目的探讨环氧化酶-2(COX-2)、血管内皮生长因子(VEGF)、微血管密度(MVD)与胃癌侵袭转移的相关性.方法采用SP免疫组化技术对82例胃癌组织、26例正常胃黏膜进行上述3个指标的检测.结果胃癌组织中COX-2、VEGF的表达及MVD计数明显高于对照组(P＜0.01),3个指标的高表达与胃癌淋巴结转移、浸润深度、TNM分期显著相关(P＜0.05),而与肿瘤大小、分化程度无关.COX-2阳性组MVD高于COX-2阴性组,COX-2与VEGF呈显著正相关性.结论COX-2与胃癌的发生及侵袭、转移有关,可能是通过参与胃癌的血管生成而起作用.

Objective] To investigate the expression level of cyclooxygenase-2(COX-2), vascular endothelial growth factor(VEGF), microvascular density(MVD) in gastric carcinoma and the relationship between their expression levewith tumor cell invasion and metastasis. [Methods] The expression of COX-2 and VEGF and MVD were studied in 82 cases with gastric carcinoma and 26 samples of normal stomach tissue by using streptavidin-peroxidase immunohistochemistry. [Results] The expression of COX-2 in gastric carcinoma was significantly higher than that of the control group. Over expression of COX-2 in gastric ca...