Tail vein injection of mmLDL upregulates mouse mesenteric artery ETB receptors via activation of the ERK1/2 pathway

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成果类型：

期刊论文

作者：

Liu, Yang;Chen, Xiao-Lan;Xu, Cang-Bao;Cao, Lei;Lin, Jie;...

通讯作者：

Li, Jie

作者机构：

[Li, Jie; Liu, Yang] Univ South China, Inst Pharm & Pharmacol, Hengyang, Hunan, Peoples R China.

[Chen, Xiao-Lan; Chen, Gen; Li, Jie; Lin, Jie] Xiangnan Univ, Peoples Hosp Chenzhou 1, Chenzhou 423000, Hunan, Peoples R China.

[Xu, Cang-Bao] Xian Med Univ, Inst Basic & Translat Med, Xian, Shaanxi, Peoples R China.

[Cao, Lei] Xi An Jiao Tong Univ, Sch Basic Med Sci, Hlth Sci Ctr, Dept Pharmacol, Xian, Shaanxi, Peoples R China.

通讯机构：

[Li, Jie] X

Xiangnan Univ, Peoples Hosp Chenzhou 1, Chenzhou 423000, Hunan, Peoples R China.

语种：

英文

关键词：

*5-hydroxytryptamine (PubChem CID: 21,701,104);*Acetylcholine (PubChem CID: 187);*Dimethylsulfoxide (PubChem CID: 21,584,481);*ERK1/2;*ET(B) receptor;*ICAM-1;*Mesenteric artery;*Sarafotoxin 6c (PubChem CID: 16,132,429);*Tail vein injection;*U0126 (PubChem CID: 3,006,531);*VCAM-1;*mmLDL

期刊：

Vascular Pharmacology

ISSN：

1537-1891

年：

2017

卷：

96-98

页码：

33-39

DOI：

10.1016/j.vph.2017.08.002

基金类别：

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81202535, 81470493]; Education Department of Hunan Province [15K114]; Health and Family Planning Commission of Hunan Province [B2017183]; Science and Technology Bureau of Chenzhou, Hunan Province, China [CZKJ2016039]

机构署名：

本校为第一机构

院系归属：

药学与生物科学学院

摘要：

Minimally modified low density lipoprotein (mmLDL) is a risk factor for cardiovascular disease. This study investigated the effect of mmLDL on mouse mesenteric artery endothelin type B (ETB) receptors and its molecular mechanism. Mice were injected with normal saline (NS group), mmLDL in the tail vein (mmLDL group), or with both mmLDL and an intraperitoneal injection of the ERK1/2 pathway-specific inhibitor U0126 (mmLDL + U0126 group). The dose-response curve of mesenteric artery contraction induced by sarafotoxin 6c (S6c), the ETB receptor agonist, was measured using a sensitive myograph syst...

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Tail vein injection of mmLDL upregulates mouse mesenteric artery ETB receptors via activation of the ERK1/2 pathway

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