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Investigation of oral toxicity of WS2 nanosheets to mouse intestine: Pathological injury, trace element balance, lipid profile changes, and autophagy

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成果类型:
期刊论文
作者:
Zha, Zhenghao;Luo, Sihuan;Wei, Lianghuan;Li, Feixing;Li, Youwen;...
通讯作者:
Li, YW;Cao, Y
作者机构:
[Li, Youwen; Zha, Zhenghao; Li, Feixing; Wei, Lianghuan] Kashi Univ, Coll Chem & Environm Sci, Xinjiang Biomass Solid Waste Resources Technol & E, Kashi 844006, Xinjiang, Peoples R China.
[Cao, Yi; Luo, Sihuan] Univ South China, Sch Publ Hlth, Hengyang Med Sch, Hunan Prov Key Lab Typ Environm Pollut & Hlth Haza, Hengyang 421001, Peoples R China.
通讯机构:
[Li, YW ] K
[Cao, Y ] U
Kashi Univ, Coll Chem & Environm Sci, Xinjiang Biomass Solid Waste Resources Technol & E, Kashi 844006, Xinjiang, Peoples R China.
Univ South China, Sch Publ Hlth, Hengyang Med Sch, Hunan Prov Key Lab Typ Environm Pollut & Hlth Haza, Hengyang 421001, Peoples R China.
语种:
英文
关键词:
autophagy;gastric administration;lipid profiles;oral toxicity;WS2 nanosheets (NSs)
期刊:
Journal of Applied Toxicology
ISSN:
0260-437X
年:
2025
卷:
45
期:
2
页码:
311-321
基金类别:
Research Projects of Kashi University; [(2022)2751]
机构署名:
本校为通讯机构
院系归属:
公共卫生学院
摘要:
The success of graphene oxides has gained extensive research interests in developing novel 2D nanomaterials (NMs). WS(2) nanosheets (NSs) are novel transition metal-based 2D NMs, but their toxicity is unclear. In this study, we investigated the oral toxicity of WS(2) NSs to mouse intestines. Male mice were administrated with vehicles, 1, 10, or 100 mg/kg NSs via intragastric route, once a day, for 5days. The results indicate that the NSs did not induce pathological or ultrastructural changes in intestines. There were minimal changes of trace e...

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