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Environmentally Relevant Concentrations of Commercial Titanium Dioxide Nanoparticles Induce Ferroptosis in HUVECs.

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成果类型:
期刊论文
作者:
Fangfang Huang;Yashi Feng;Zi-An Wang;Yunchang Cao;Qiong Yan;...
通讯作者:
Shaolong Feng
作者机构:
[Zi-An Wang] The School of Medicine & Holistic Integrative Medicine, Nanjing University of Chinese Medicine, Nanjing, China
[Fangfang Huang; Yashi Feng] The Guangxi Key Laboratory of Environmental Exposomics and Entire Lifecycle Heath, School of Public Health, Guilin Medical University, Guilin, China
[Yunchang Cao] The Department of Molecular Biology, School of Intelligent Medicine and Biotechnology, Guilin Medical University, Guilin, China
[Wuxiang Wang] The School of Public Health, University of South China, Hengyang, China
The State Key Laboratory of Organic Geochemistry, Guangzhou Institute of Geochemistry, Chinese Academy of Sciences, Guangzhou, China
通讯机构:
[Shaolong Feng] T
The Guangxi Key Laboratory of Environmental Exposomics and Entire Lifecycle Heath, School of Public Health, Guilin Medical University, Guilin, China<&wdkj&>The School of Public Health, University of South China, Hengyang, China<&wdkj&>The State Key Laboratory of Organic Geochemistry, Guangzhou Institute of Geochemistry, Chinese Academy of Sciences, Guangzhou, China
语种:
英文
关键词:
Ferroptosis;NrF2;endothelial cell (EC);titanium dioxide nanoparticle (TiO2‐NP)
期刊:
ENVIRONMENTAL TOXICOLOGY
ISSN:
1520-4081
年:
2025
基金类别:
This work was supported by National Natural Science Foundation of China, 41877390 and Foundation of State Key Laboratory of Organic Geochemistry, GIGCAS, SKLOG-202213. Fangfang Huang and Yashi Feng have contributed equally to this work and share first authorship.
机构署名:
本校为通讯机构
院系归属:
公共卫生学院
摘要:
Titanium dioxide nanoparticles (TiO(2)-NPs) have been ever increasingly exposed to people through all possible routes, while studies focusing on their potential cardiovascular risks are relatively lacking, especially the underlying biological mechanisms that are not yet elucidated. In this study, the ferroptotic effect of TiO(2)-NPs (30 nm) at environmentally relevant concentrations (0, 3, 12, and 48 μg/mL) on human umbilical vein endothelial cells (HUVECs) and the potential molecular mechanism were studied with the corresponding biochemical...

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