Betaine eliminates CFA-induced depressive-like behaviour in mice may be through inhibition of microglia and astrocyte activation and polarization

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成果类型：

期刊论文

作者：

Liang, Yue;Chen, Ling;Huang, Yanmei;Xie, Lihua;Liu, Xueqin;...

通讯作者：

Zhong, XL;Chen, ZY

作者机构：

[Zhou, Wenyan; Zhong, Xiaolin; Liang, Yue; Liu, Xueqin; Chen, Ling] Univ South China, Affiliated Hosp 1, Hengyang Med Sch, Dept Endocrinol & Metab, Hengyang 421001, Hunan, Peoples R China.

[Huang, Yanmei; Liang, Yue; Xie, Lihua] Univ South China, Affiliated Hosp 1, Hengyang Med Sch, Dept Lab Med, Hengyang 421001, Hunan, Peoples R China.

[Cao, Wenyu] Univ South China, Hengyang Med Sch, Dept Human Anat, Hengyang 421001, Hunan, Peoples R China.

[Chen, Zuyao; Chen, ZY] Univ South China, Affiliated Hosp 1, Hengyang Med Sch, Dept Otorhinolaryngol, Hengyang 421001, Hunan, Peoples R China.

通讯机构：

[Zhong, XL ; Chen, ZY ] U

Univ South China, Affiliated Hosp 1, Hengyang Med Sch, Dept Endocrinol & Metab, Hengyang 421001, Hunan, Peoples R China.

Univ South China, Affiliated Hosp 1, Hengyang Med Sch, Dept Otorhinolaryngol, Hengyang 421001, Hunan, Peoples R China.

语种：

英文

关键词：

Betaine;Microglia polarization;Astrocyte polarization;Pain-related depressive-like behaviour

期刊：

Brain Research Bulletin

ISSN：

0361-9230

年：

2024

卷：

206

页码：

110863

DOI：

10.1016/j.brainresbull.2023.110863

基金类别：

National Natural Science Foundation of China [81901147, 82100537]; Hunan Provincial Natural Science Foundation of China [2023JJ30553, 2023JJ30537]; Education Sci-entific Research Project of Hunan Provincial [23A0341]

机构署名：

本校为第一且通讯机构

院系归属：

医学院

摘要：

Chronic pain can induce not only nociceptive but also depressive emotions. A previous study demonstrated that betaine, a commonly used nutrient supplement, has an anti-nociceptive effect, but whether betaine can alleviate chronic pain-induced depressive emotion is elusive. Our current study found that betaine administration significantly eliminated complete Freund's adjuvant (CFA)-induced pain-related depressive-like behaviour. Mechanistically, betaine treatment inhibited microglia and astrocyte activation. Furthermore, betaine significantly pr...

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Betaine eliminates CFA-induced depressive-like behaviour in mice may be through inhibition of microglia and astrocyte activation and polarization

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