National Natural Science Foundation of China [81973326]; Natural Science Foundation of Hunan Province, China [2022JJ30484]; University of South China [201RGC012]; State Key Laboratory of Chemo/Biosensing and Chemometrics [2021013]
机构署名：
本校为第一且通讯机构
院系归属：
药学与生物科学学院
摘要：
Ferrous ion (Fe2+) is a crucial metal ion in the body and participates in the diseases related to oxidation and reduction. Golgi apparatus is the main subcellular organelle of Fe2+ transport in cells, and the stability of its structure is related to the Fe2+ at an appropriate concentration. In this work, a turn-on type Golgi-targeting fluorescent chemosensor Gol-Cou-Fe2+ was rationally designed for sensitive and selective detection of Fe2+. Gol-Cou-Fe2+ showed excellent capacity of detecting exogenous and endogenous Fe2+ in HUVEC and HepG2 cells. It was used to capture the up-regulated Fe2+ le...
