New insights into mTOR signal pathways in ovarian-related diseases: Polycystic ovary syndrome and ovarian cancer

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Liu, Ai Ling*;Liao, Hong Qing;Li, Zhi Liang;Liu, Jun;Zhou, Cui Lan;...

通讯作者：

Liu, Ai Ling

作者机构：

[Xie, Hong Yan; Li, Zhi Liang; Peng, Cui Ying; Liu, Ai Ling; Liu, Jun] Institute of Biological Science, The Key Laboratory of Biological Toxicology and Ecological Restoration of Hengyang City, School of Pharmaceutical and Biological Science, Heng Yang, Hunan Province, 421001, China

[Liao, Hong Qing] Reproductive Health Hospital of Nanhua-Xinghui in Hengyang City, Heng Yang, Hunan Province, 421001, China

[Zhou, Cui Lan] Department of Anatomy, University of South China, Heng Yang, Hunan Province, 421001, China

[Guo, Zi Fen] Institute of Pharmacy and Pharmacology, University of South China, Heng Yang, Hunan Province, 421001, China

通讯机构：

[Liu, Ai Ling] I

Institute of Biological Science, The Key Laboratory of Biological Toxicology and Ecological Restoration of Hengyang City, School of Pharmaceutical and Biological Science, University of South China, Heng yang 421001, Hunan Province, China. Email:

语种：

英文

关键词：

mTOR signaling pathway;PCOS;ovarian cancer

期刊：

Asian Pacific Journal of Cancer Prevention

ISSN：

1513-7368

年：

2016

卷：

期：

页码：

5087-5094

DOI：

10.22034/APJCP.2016.17.12.5087

机构署名：

本校为第一且通讯机构

院系归属：

医学院

药学与生物科学学院

摘要：

mTOR, the mammalian target of rapamycin, is a conserved serine/threonine kinase which belongs to the phosphatidyl-linositol kinase-related kinase (PIKK) family. It has two complexes called mTORC1 and mTORC2. It is well established that mTOR plays important roles in cell growth, proliferation and differentiation. Over-activation of the mTOR pathway is considered to have a relationship with the development of many types of diseases, including polycystic ovary syndrome (PCOS) and ovarian cancer (OC). mTOR pathway inhibitors, such as rapamycin and its derivatives, can directly or indirectly treat ...

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New insights into mTOR signal pathways in ovarian-related diseases: Polycystic ovary syndrome and ovarian cancer

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