Cognitive protection of sinomenine in type 2 diabetes mellitus through regulating the EGF/Nrf2/HO‐1 signaling, the microbiota‐gut‐brain axis, and hippocampal neuron ferroptosis

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成果类型：

期刊论文

作者：

Chen, Ji;Guo, Peng;Han, Mingming;Chen, Kemin;Qin, Jie;...

通讯作者：

Fengrui Yang<&wdkj&>Fengrui Yang Fengrui Yang Fengrui Yang

作者机构：

[Chen, Ji] First Peoples Hosp Huaihua, Dept Endocrinol, Huaihua, Peoples R China.

[Guo, Peng; Yang, Fengrui] First Peoples Hosp Huaihua, Dept Anesthesiol, Huaihua, Peoples R China.

[Han, Mingming] Univ Sci & Technol China, Affiliated Hosp USTC 1, Dept Anesthesiol, Div Life Sci & Med, Hefei, Peoples R China.

[Qin, Jie; Chen, Kemin; Yang, Fengrui] Univ South China, Affiliated Hosp 1, Dept Anesthesiol, Hengyang, Peoples R China.

[Yang, Fengrui] First Peoples Hosp Huaihua, Dept Anesthesiol, 144 Jinxi South Rd, Huaihua 418000, Hunan, Peoples R China.

通讯机构：

[Fengrui Yang; Fengrui Yang Fengrui Yang Fengrui Yang] D

Department of Anesthesiology, The First People's Hospital of Huaihua, Huaihua, P.R. China<&wdkj&>Department of Anesthesiology, The First Affiliated Hospital, University of South China, Hengyang, P.R. China

语种：

英文

关键词：

EGF;Nrf2/HO-1 signaling pathway;Sinomenine;cognitive dysfunction;ferroptosis;microbiota-gut-brain axis;type 2 diabetes mellitus

期刊：

Phytotherapy Research

ISSN：

0951-418X

年：

2023

卷：

期：

页码：

3323-3341

DOI：

10.1002/ptr.7807

基金类别：

Natural Science Foundation of Hunan Province [2021JJ70043]; Project of Hunan Provincial Health Commission [20200018, 20200037]; Education Department of Hunan Province [19B477]

机构署名：

本校为其他机构

院系归属：

医学院

摘要：

Recent years have witnessed a growing research interest in traditional Chinese medicine as a neuroprotective nutrient in the management of diabetic cognitive dysfunction. However, the underlying molecular mechanisms of sinomenine in mediating ferroptosis of hippocampal neurons have been poorly understood. This study sought to decipher the potential effect and molecular mechanism of sinomenine in the cognitive dysfunction following type 2 diabetes mellitus (T2DM). Multi-omics analysis was conducted to identify the microbiota-gut-brain axis in T2DM patient samples obtained from the publicly avai...

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Cognitive protection of sinomenine in type 2 diabetes mellitus through regulating the EGF/Nrf2/HO‐1 signaling, the microbiota‐gut‐brain axis, and hippocampal neuron ferroptosis

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