Pro-oncogene Pokemon promotes breast cancer progression by upregulating survivin expression

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成果类型：

期刊论文

作者：

Zu, Xuyu;Ma, Jun;Liu, Hongxia;Liu, Feng;Tan, Chunyan;...

通讯作者：

Jiang, Yuyang

作者机构：

[Wang, Jue; Jiang, Yuyang; Tan, Chunyan; Liu, Hongxia; Xie, Zhenhua; Liu, Feng; Zu, Xuyu; Yu, Lingling] Tsinghua Univ, Grad Sch Shenzhen, Guangdong Prov Key Lab Chem Biol, Shenzhen 518055, Peoples R China.

[Zu, Xuyu] Univ S China, Inst Clin Med, Affiliated Hosp 1, Hengyang 421001, Peoples R China.

[Ma, Jun; Cao, Deliang] So Illinois Univ, Simmons Canc Inst, Dept Med Microbiol Immunol & Cell Biol, Sch Med, Springfield, IL 62794 USA.

[Jiang, Yuyang] Tsinghua Univ, Sch Med, Beijing 100084, Peoples R China.

[Jiang, Yuyang] Tsinghua Univ, Grad Sch Shenzhen, Guangdong Prov Key Lab Chem Biol, Lishui Rd, Shenzhen 518055, Peoples R China.

通讯机构：

[Jiang, Yuyang] T

Tsinghua Univ, Grad Sch Shenzhen, Guangdong Prov Key Lab Chem Biol, Lishui Rd, Shenzhen 518055, Peoples R China.

语种：

英文

关键词：

Breast Cancer;Epidermal Growth Factor Receptor;Breast Cancer Tissue;Survivin Expression;Cartilage Oligomeric Matrix Protein

期刊：

BREAST CANCER RESEARCH

ISSN：

1465-5411

年：

2011

卷：

期：

页码：

1-11

DOI：

10.1186/bcr2843

基金类别：

This work was supported by a grant from National 863 Project of the Ministry of Science and Technology (China, 2007AA02Z160). The authors thank the Ministry of Science and Technology of China (2009ZX09501-004 and 2007AA02Z160) and the Chinese National Natural Science Foundation (20872077 and 90813013) for financial support.

机构署名：

本校为其他机构

院系归属：

医学院

摘要：

Pokemon is an oncogenic transcription factor involved in cell growth, differentiation and oncogenesis, but little is known about its role in human breast cancer. In this study, we aimed to reveal the role of Pokemon in breast cancer progression and patient survival and to understand its underlying mechanisms. Tissue microarray analysis of breast cancer tissues from patients with complete clinicopathological data and more than 20 years of follow-up were used to evaluate Pokemon expression and its correlation with the progression and prognosis of the disease. DNA microarray analysis of MCF-7 cel...

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Pro-oncogene Pokemon promotes breast cancer progression by upregulating survivin expression

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