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Cytoplasmic Polyadenylation Element Binding Protein 1 and Atherosclerosis: Prospective Target and New Insights

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成果类型:
期刊论文
作者:
Zhou, Jing;Tang, Chao-Ke
通讯作者:
Tang, CK
作者机构:
[Tang, Chao-Ke; Zhou, Jing] Univ South China, Inst Cardiovasc Dis, Sch Pharmacol, Hengyang Med Sch,Key Lab Arteriosclerol Hunan Prov, Hunan421001, Hengyang, Peoples R China.
[Tang, Chao-Ke; Tang, CK] Univ South China, Inst Cardiovasc Dis, Hengyang 421001, Hunan, Peoples R China.
通讯机构:
[Tang, CK ] U
Univ South China, Inst Cardiovasc Dis, Hengyang 421001, Hunan, Peoples R China.
语种:
英文
关键词:
CPEB1;apoptosis;atherosclerosis;endothelial dysfunction;inflammation;oxidative stress
期刊:
CURRENT VASCULAR PHARMACOLOGY
ISSN:
1570-1611
年:
2024
卷:
22
期:
2
页码:
95-105
机构署名:
本校为第一且通讯机构
院系归属:
医学院
摘要:
The ribonucleic acid (RNA)-binding protein Cytoplasmic Polyadenylation Element Binding Protein 1 (CPEB1), a key member of the CPEB family, is essential in controlling gene expression involved in both healthy physiological and pathological processes. CPEB1 can bind to the 3'- untranslated regions (UTR) of substrate messenger ribonucleic acid (mRNA) and regulate its translation. There is increasing evidence that CPEB1 is closely related to the pathological basis of atherosclerosis. According to recent investigations, many pathological processes, including inflammation, lipid metabolism, endothel...

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