Group 2 innate lymphoid cells(ILC2s)are a group of innate immune cells that lack specific antigen recognition receptors,which can be activated by IL-33,IL-25 and thymic stromal lymphopoietin(TSLP)and produce type 2 cytokines,such as IL-5 and IL-13,which exert an anti-parasitic infection effect. Studies have found that the excessive activation of ILC2 is closely associated with development of many inflammatory diseases,such as asthma and dermatitis. Suppressing activation of ILC2 has become an important strategy for treatment of ILC2-induced diseases. Regulatory T cells(Tregs)are important CD4T...
