期刊论文

Role of TOLL-like receptor 4/MAPKs pathway of renal tissue in diabetic rats by pioglitazone

中文

中国免疫学杂志

Chinese Journal of Immunology

1000-484X

2016

32

12

1769-1772

10.3969/j.issn.1000-484X.2016.12.009

本校为其他机构

目的:探讨吡格列酮对糖尿病肾病大鼠肾组织中TOLL受体4 /MAPKs信号通路的影响。方法:将雄性SD随机分为对照组(n= 8)和试验组(n= 32) 。试验组SD鼠造模成功后随机分为3组进行干预,应用Western blot检测对照组和干预组大鼠肾组织中丝裂原活化蛋白激酶ERK1 /2及p38MAPK磷酸化水平。结果:与对照组比较,各组大鼠肾组织中TOLL受体4表达增强,其中ERK1 /2与JNK磷酸化水平明显升高(P0. 05) ;与模型组比较,吡咯列酮干预组大鼠肾组织中ERK1 /2与p38MAPK磷酸化水平降低(P

Objective: To study the role of TOLL-like receptor4 /MAPKs pathway of renal tissue in the diabetic rats treated with piogitazone. Methods: The male Sprague Dawlry rats were randomly selected as the control group (n= 8) and experimental group(n = 32) . The experimental rats were randomly divided into three groups. The expression of ERK1 /2, JNK and p38MAPK, and levels of their phosphorylation in kidney were measured by Western blot in control group and experimental group. Results: The expression of TOLLlike receptor 4 in all renal tissue in the diabetic rats were significantlyincreased than tho...