期刊论文

中文

中国免疫学杂志

1000-484X

2014

30

3

383-387

10.3969/j.issn.1000-484X.2014.03.020

本文为国家自然科学基金（No.30770155）和湖南省自然科学基金（No.12JJ3105）.

本校为其他机构

目的:研究吡格列酮对糖尿病大鼠肾组织TLR4及PPARγ 表达变化规律及其意义。方法:取57只5周龄180 ~ 200 g的清洁级雄性Sprague Dawley(SD)大鼠,随机分为正常对照组(A 组,n = 9)和造模组(n = 48)。造模组给予腹腔注射链脲佐菌素(streptozocin,STZ, 50 mg /kg)诱导大鼠成糖尿病模型(其中3只造模未成功)。将造模成功的40只大鼠随机分为:吡格列酮5 mg /(kg·d)(B 组,n = 9),吡格列酮10 mg /(kg·d)组(C 组,n = 9),吡格列酮5 mg /(kg·d)+ TLR4特异性抑制剂Eritoran 5 mg /(kg·d)(D 组,n = 9),吡格列酮10 mg /(kg·d)+ TLR4特异性抑制剂Eritoran 5 mg /(kg·d)(E 组,n =9),未干预组(F 组,n = 9),于第...

Objective：To investigate the expression patterns of Toll-like receptor4（TLR4） and PPARγ in rats with diabetic ne- phropathy and it potential significance by pioglitazone interfered. Methods： 57 healthy male Sprague Dawlry rats were randomly select- ed as the control group（ group A, n = 9 ） , the other 48 rats given streptozotocin （STZ ,50 mg/kg） were made as the model of a diabetic rats（3 cases failed to achieve the standard of diabetes was excluded） , and they were randomly divided into five groups with nine in each ： low-dose piog...