Aptamer Selection of Radiation-Sensitive Protein p21 and Electrical Impedance Detection-Based Applications in Radiation Dose Assessment

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成果类型：

期刊论文

作者：

Bai, Chenjun;Zhang, Tinghui;Wu, Tao;Wang, Yuting;Yao, Shibo;...

通讯作者：

Zhou, PK;Huang, RX

作者机构：

[Zhou, Pingkun; Zhang, Tinghui; Tan, Jinpeng; Wang, Yuting; Yao, Shibo; Bai, Chenjun; Wang, Cui] Beijing Inst Radiat Med, Dept Radiat Biol, Beijing Key Lab Radiobiol, Beijing 100850, Peoples R China.

[Wu, Tao] Capital Med Univ, Beijing Friendship Hosp, Dept Neurosurg, Beijing, Peoples R China.

[Tan, Jinpeng] Univ South China, Coll Publ Hlth, Hengyang Med Sch, Hengyang 421001, Hunan, Peoples R China.

[Huang, RX; Huang, Ruixue] Cent South Univ, Xiangya Sch Publ Hlth, Dept Occupat & Environm Hlth, Changsha 410078, Hunan, Peoples R China.

通讯机构：

[Zhou, PK ] B

[Huang, RX ] C

Beijing Inst Radiat Med, Dept Radiat Biol, Beijing Key Lab Radiobiol, Beijing 100850, Peoples R China.

Cent South Univ, Xiangya Sch Publ Hlth, Dept Occupat & Environm Hlth, Changsha 410078, Hunan, Peoples R China.

语种：

英文

关键词：

Aptasensor;Dose assessment;Electrochemical impedance aptasensor;Radiation biodosimeters;p21 protein

期刊：

Biosensors and Bioelectronics

ISSN：

0956-5663

年：

2025

卷：

282

页码：

117447

DOI：

10.1016/j.bios.2025.117447

机构署名：

本校为其他机构

院系归属：

公共卫生学院

摘要：

Radiation dose assessment is the main basis for the diagnosis of acute radiation sickness. At present, there is a lack of rapid and portable dose assessment methods, which has an important impact on the rapid diagnosis and precise treatment of radiation accident patients and nuclear practitioners. We selected and obtained specific aptamers for radiation-sensitive protein p21 protein by the magnetic cross-linking precipitation (MCP)-SELEX procedure. The aptamer has a high affinity for binding to the p21 protein and its K d value is 2.21×10 -7 m...

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