期刊论文

Apolipoprotein-I Protectes Against lipopolysaccharide-induced Acute Hepatic Injury in Mice

中文

湖南师范大学学报(医学版)

1673-016X

2010

7

3

8-10+13

10.3969/j.issn.1673-016X.2010.03.003

湖南省科技厅资助项目（2008SK3072）；

本校为第一机构

目的:研究载脂蛋白A-I（ApoA-I）对内毒素血症小鼠肝组织的保护作用。方法:建立内毒素血症小鼠急性肝损伤模型,观察人血浆ApoA-I处理后各组小鼠肝脏的组织学改变,RT-PCR检测小鼠肝脏CD14的表达。结果:内毒素血症肝损伤小鼠肝脏发生了明显坏死,而ApoA-I治疗组小鼠肝脏仅发生轻微坏死;内毒素血症小鼠肝脏组织CD14mRNA表达水平明显增高,ApoA-I治疗后,CD14mRNA表达水平下降（P

Objective To investigate the protective effect of human Apolipoprotein-I(ApoA-I) on the acute hepatic injury induced by lipopolysaccharide in mice.Methods The mouse model with acute hepatic damage was established by endotoxin and galactosamine.The histological alterations of the liver organs were observed.The mRNA expressions of CD14 were detected by RT-PCR.Results Extensive degeneration and necrosis of the hepatocytes were found in the control group,however,slight degeneration and necrosis of the hepatocytes occurred in the ApoA-I-treated group.The mRNA expression levels of CD14 in the liver ...