期刊论文

Xiong, X.-W.

中文

湖南师范大学自然科学学报

2096-5281

2004

27

1

71-74

10.3969/j.issn.1000-2537.2004.01.018

教育部重点课题； 湖南省教育厅重点课题；

本校为其他机构

B12是一种受TNF-α诱导的蛋白.利用肝脏部分切除小鼠模型以及核酸酶保护反应研究了B12基因在肝脏部分切除后不同时间的表达差异,发现在受损后28 h,B12的表达开始增强,到36 h表达一直呈上升趋势,推测该基因可能与肝脏修复过程中DNA的复制有关,为B12基因的进一步的功能研究提供了理论基础.

B12 is a sort of protein induced by TNF-α. Used mouse partial hepatectomy(PHx) model and ribonuclease protection assay(RPA) to study the expression of B12 after the surgical removal of the liver at different recovery time-points. The results showed that 28 h after PHx, the expression of B12 began to increase, and the trend of increasing prolonged to 36 h after PHx. These suggest that B12 might be involved in DNA replication in liver regeneratio...