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Immune checkpoint inhibitors for patients with microsatellite instability-high colorectal cancer: protocol of a pooled analysis of clinical trials

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成果类型:
期刊论文
作者:
Tang, Xiaojun;Xu, Xinshu;Chen, Ruobing;Zhang, Mengmeng;Mei, Zubing;...
通讯作者:
Zhang, SX;Mei, ZB
作者机构:
[Tang, Xiaojun] Univ South China, Affiliated Hosp 2, Hengyang Med Sch, Dept Spinal Surg, Hengyang, Hunan, Peoples R China.
[Xu, Xinshu; Chen, Ruobing; Zhang, Shuangxi; Zhang, Mengmeng] Henan Univ Chinese Med, Dept Anorectal Surg, Affiliated Hosp 1, Zhengzhou, Henan, Peoples R China.
[Xu, Xinshu; Chen, Ruobing; Zhang, Mengmeng] Henan Univ Chinese Med, Clin Med Coll 1, Zhengzhou, Henan, Peoples R China.
[Mei, Zubing; Mei, ZB] Shanghai Univ Tradit Chinese Med, Shuguang Hosp, Dept Anorectal Surg, Shanghai, Peoples R China.
[Mei, Zubing; Mei, ZB] Shuguang Hosp, Anorectal Dis Inst, Shanghai, Peoples R China.
通讯机构:
[Zhang, SX ] H
[Mei, ZB ] S
Henan Univ Chinese Med, Dept Anorectal Surg, Affiliated Hosp 1, Zhengzhou, Henan, Peoples R China.
Shanghai Univ Tradit Chinese Med, Shuguang Hosp, Dept Anorectal Surg, Shanghai, Peoples R China.
Shuguang Hosp, Anorectal Dis Inst, Shanghai, Peoples R China.
语种:
英文
关键词:
clinical trials;colorectal cancer;immune checkpoint inhibitors;microsatellite instability-high;pooled analysis
期刊:
FRONTIERS IN ONCOLOGY
ISSN:
2234-943X
年:
2024
卷:
13
页码:
1331937
基金类别:
Key Research and Promotion Project of Henan Province (Science and Technology Tackling Project) [232102311221]; Hunan Provincial Natural Science Foundation of China [2022JJ30519]; Scientific Research Fund of Hunan Provincial Health Commission [20200968]; Scientific Research Fund of Hengyang Science and Technology Bureau [2019jh010988]
机构署名:
本校为第一机构
摘要:
INTRODUCTION: Colorectal cancer (CRC) is the third most common cause of cancer and the second leading cause of cancer-related deaths worldwide. Microsatellite instability-high (MSI-H) is a distinct molecular subtype of CRC that occurs in approximately 15% of all cases. Recently, immune checkpoint inhibitors (ICIs) have emerged as a promising therapeutic approach for patients with MSI-H colorectal cancer, exhibiting higher response rates than standard chemotherapies. To assess the effectiveness and safety of ICIs for the treatment of patients wi...

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