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Cytotoxic lipid esters from Peucedanum ledebourielloides

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成果类型:
期刊论文
作者:
Zheng, Xing*;Du, Jiang;Xu, Yunlong;Liao, Duanfang;Pettit, George R.
通讯作者:
Zheng, Xing
作者机构:
[Liao, Duanfang; Zheng, Xing] Nanhua Univ, Inst Pharm & Pharmacol, Hengyang 421001, Peoples R China.
[Pettit, George R.; Zheng, Xing] Arizona State Univ, Dept Chem & Biochem, Tempe, AZ 85287 USA.
[Du, Jiang] Colorado State Univ, Dept Chem, Ft Collins, CO 80526 USA.
[Xu, Yunlong] Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China.
通讯机构:
[Zheng, Xing] N
Nanhua Univ, Inst Pharm & Pharmacol, Hengyang 421001, Peoples R China.
语种:
英文
关键词:
Apiaceae family;Peucedanum ledebourielloides;Ester;Anticancer
期刊:
Medicinal Chemistry Research
ISSN:
1054-2523
年:
2010
卷:
19
期:
4
页码:
337-343
基金类别:
Department of Education of Hunan [07B065]; Department Science and Technology of Hunan [2007FJ4155]; Division of Cancer Treatment and DiagnosisUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Cancer Institute (NCI)NIH National Cancer Institute- Division of Cancer Treatment & Diagnosis [CA90441-5, CA90441-06A1]; National Cancer InstituteUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Cancer Institute (NCI); DHHS; Arizona Biomedical Research Commission
机构署名:
本校为第一且通讯机构
院系归属:
药学与生物科学学院
摘要:
Two cancer cell growth inhibitory esters, 1,2-dipalmitoyl-3-glucosyl glycerol (1) and 1,6-dihydroxy-hexane-bis-palmitoyl ester (2), together with arachidic acid-2-hydroxy-glycerol ester, daucosterol, and oleanolic acid, were isolated from the roots of Peucedanum ledebourielloides (Apiaceae family). The structures were determined by spectroscopic analyses. The esters 1 and 2 displayed significant activity against...

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