Synthesis of a Triple-Responsive Double Hydrophilic Block Copolymer Prodrug Using a Reducible RAFT-ATRP Double-Head Agent

首页 > 成果 > 详情

认领

导出

下载 Link by DOI

反馈

作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Sun, Lu;Zhou, Yang;Zhou, Xufeng;Ma, Liwei;Wang, Baoyan;...

通讯作者：

Yu, Cuiyun;Wei, Hua

作者机构：

[Wei, Hua; Sun, Lu; Yu, Cuiyun; Wei, H] Univ South China, Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, Hengyang 421001, Peoples R China.

[Wei, Hua; Sun, Lu; Yu, Cuiyun; Wei, H] Univ South China, Dept Pharm & Pharmacol, Hengyang 421001, Peoples R China.

[Wei, Hua; Ma, Liwei; Zhou, Yang; Sun, Lu; Wang, Baoyan; Zhou, Xufeng] Lanzhou Univ, State Key Lab Appl Organ Chem, Key Lab Nonferrous Met Chem & Resources Utilizat, Lanzhou 730000, Gansu, Peoples R China.

[Wei, Hua; Ma, Liwei; Zhou, Yang; Sun, Lu; Wang, Baoyan; Zhou, Xufeng] Lanzhou Univ, Coll Chem & Chem Engn, Lanzhou 730000, Gansu, Peoples R China.

通讯机构：

[Yu, CY; Wei, H] U

[Wei, Hua] L

Univ South China, Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, Hengyang 421001, Peoples R China.

Univ South China, Dept Pharm & Pharmacol, Hengyang 421001, Peoples R China.

Lanzhou Univ, State Key Lab Appl Organ Chem, Key Lab Nonferrous Met Chem & Resources Utilizat, Lanzhou 730000, Gansu, Peoples R China.

语种：

英文

关键词：

DHBC;thermo-sensitivity;reduction-sensitivity;pH sensitivity;polymeric prodrug;RAFT;ATRP

期刊：

ACS APPLIED POLYMER MATERIALS

ISSN：

2637-6105

年：

2020

卷：

期：

页码：

2126-2133

DOI：

10.1021/acsapm.0c00083

基金类别：

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [51473072, 21504035]; Thousand Young Talent Program; Outstanding Youth Fund of Natural Science Foundation of Hunan ProvinceNatural Science Foundation of Hunan Province [2017JJ1024]; National Key R&D Program of China [2018YFB1900201]; Open Research Fund of State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences

机构署名：

本校为第一且通讯机构

院系归属：

药学与生物科学学院

摘要：

Reduction- and acidic-pH-dual-sensitive micelles have been frequently highlighted to present a synergistic effect on the promotion of intracellular drug release for enhanced therapeutic efficiency compared to the delivery systems based on a single biorelevant trigger. However, the preparation of dual-responsive block copolymers with well-defined structures, especially for those with a reducible backbone, are highly desirable for polymer degradation but still suffer from less control, tedious purification, and low efficiency, likely due to the a...

反馈

产权有误：本人成果被他人认领

数据有误：数据基本信息有误

归属有误：成果的院系归属、机构署名归属有误

其他原因：

验证码：

看不清楚，换一个

确定

取消

成果认领

标题：

用户	作者	通讯作者	--
	请选择	请选择	--

确定

取消

Synthesis of a Triple-Responsive Double Hydrophilic Block Copolymer Prodrug Using a Reducible RAFT-ATRP Double-Head Agent

反馈

成果认领

提示

该栏目需要登录且有访问权限才可以访问