期刊论文

中文

免疫学杂志

1000-8861

2022

38

9

804-809

湖南省卫生健康委2019年度科研计划课题项目（C2019103）；

本校为第一机构

目的 探讨罗汉果皂苷Ⅵ对膝骨关节炎大鼠软骨损伤的影响及其作用机制。方法 采用改良Hulth法制备大鼠膝骨关节炎模型，将大鼠随机分为模型组、硫酸氨基葡萄糖组（阳性对照，0.17 g/kg）、罗汉果皂苷Ⅵ低剂量组（27.5 mg/kg）和高剂量组（110 mg/kg），另设置假手术组，每组12只。各组给予相应药物灌胃干预，1次/d，连续8周。观察右侧膝关节肿胀程度；HE染色观察软骨组织病理学变化；ELISA检测软骨组织中IL-1β、IL-6、TNF-α和MMP-13表达水平；Western blot检测软骨组织中Cleaved-caspase-3、Bcl-2、Bax、p38MAPK、p-p38MAPK、MMP-13和NF-κB p65等蛋白表达水平。结果 与假手术组比较，模型组右...

To investigate the effects of mogrosideⅥon cartilage injury in rats with knee osteoarthritis and the mechanism.The knee osteoarthritis rats were prepared by an improved Hulth method,and then randomly divided into model group,glucosamine sulfate group(positive control,0.17 g/kg),mogrosideⅥlow-dose group(27.5 mg/kg)and high-dose group(110 mg/kg),with 12 in each group,and another 12 rats were recruited as sham operation group.Rats in each group were given relevant drug intragastric intervention,once a day,for consecutive 8 weeks.The swelling deg...