Artesunate inhibits atherosclerosis by upregulating vascular smooth muscle cells-derived LPL expression via the KLF2/NRF2/TCF7L2 pathway

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成果类型：

期刊论文

作者：

He, Lin-Hao;Gao, Jia-Hui;Yu, Xiao-Hua;Wen, Feng-Jiao;Luo, Jing-Jing;...

通讯作者：

Tang, Chao-Ke;Wang, Zong-Bao

作者机构：

[Wen, Feng-Jiao; Qin, Yu-Sheng; Tang, Chao-Ke; Yu, Xiao-Hua; Wang, Zong-Bao; He, Lin-Hao; Chen, Ming-Xin; Gao, Jia-Hui; Luo, Jing-Jing] Univ South China, Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, Hengyang Med Coll,Hunan Int Sci & Technol Coopera, Inst Cardiovasc Dis,Key Lab Arteriosclerol Hunan, Hengyang 421001, Hunan, Peoples R China.

[Tang, Chao-Ke; Wang, Zong-Bao; He, Lin-Hao; Chen, Ming-Xin; Luo, Jing-Jing] Univ South China, Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, Sch Pharmaceut Sci, Hengyang 421001, Hunan, Peoples R China.

[Zhang, Da-Wei] Univ Alberta, Dept Pediat, Edmonton, AB T6G 2S2, Canada.

[Zhang, Da-Wei] Univ Alberta, Grp Mol & Cell Biol Lipids, Edmonton, AB T6G 2S2, Canada.

[Wang, Zong-Bao] Univ South China, Sch Pharmaceut Sci, Hengyang 421001, Hunan, Peoples R China.

通讯机构：

[Tang, Chao-Ke; Wang, Zong-Bao] U

Univ South China, Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, Hengyang Med Coll,Hunan Int Sci & Technol Coopera, Inst Cardiovasc Dis,Key Lab Arteriosclerol Hunan, Hengyang 421001, Hunan, Peoples R China.

Univ South China, Sch Pharmaceut Sci, Hengyang 421001, Hunan, Peoples R China.

语种：

英文

关键词：

Artesunate;Atherosclerosis;KLF2;LPL;NRF2;TCF7L2

期刊：

European Journal of Pharmacology

ISSN：

0014-2999

年：

2020

卷：

884

期：

页码：

173408

DOI：

10.1016/j.ejphar.2020.173408

基金类别：

CRediT authorship contribution statement Lin-Hao He: Conceptualization, Formal analysis, Software, Methodology, Visualization. Jia-Hui Gao: Conceptualization, Writing - original draft. Xiao-Hua Yu: Methodology, Validation, Writing - review & editing. Feng-Jiao Wen: Methodology, Validation. Jing-Jing Luo: Methodology, Validation. Yu-Sheng Qin: Software, Methodology. Ming-Xin Chen: Software, Methodology. Da-Wei Zhang: Writing - review & editing. Zong-Bao Wang: Resources, Supervision, acquisition. Chao-Ke Tang: Resources,

机构署名：

本校为第一且通讯机构

院系归属：

医学院

药学与生物科学学院

摘要：

Lipoprotein lipase (LPL) plays a central role in hydrolyzing triglyceride and its deficiency leads to atherosclerosis. Artesunate (ART), a derivative of artemisinin, has been demonstrated that ART reduces the formation of atherosclerotic plaques. However, it remains unclear whether ART-alleviated atherosclerotic lesion is involved in regulating lipid metabolism. ApoE-/- mice were fed a high-fat diet to form atherosclerotic plaques and then injected with artesunate or not. Oil Red O, HE and Masson staining were performed to assess atheroscleroti...

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Artesunate inhibits atherosclerosis by upregulating vascular smooth muscle cells-derived LPL expression via the KLF2/NRF2/TCF7L2 pathway

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