期刊论文

In vitro activity of 6 fluoroquinolones against Mycoplasma hominis

中文

中国感染与化疗杂志

1009-7708

2003

3

1

8-10

10.3321/j.issn:1009-7708.2003.01.003

湖南省教委科研项目

本校为第一机构

目的:检测氟喹诺酮类药物对人型支原体(Mh)临床株的抗微生物作用,指导临床合理用药. 方法:以微量肉汤稀释法检测103株Mh对6种氟喹诺酮类药物的敏感性. 结果:在6种药物中司帕沙星和加替沙星抗Mh活性最强,MIC50分别为0.03125mg /L和0.25mg /L,MIC90均为1mg /L.其次为左氧氟沙星MIC50和MIC90分别为1mg /L和4mg /L,氧氟沙星和环丙沙星的MIC50和MIC90均分别为2mg /L和8mg /L.诺氟沙星的抗Mh活性最差,其 MIC50和MIC90分别达到32mg /L和64mg /L.结论:氟喹诺酮类抗菌药新品种司帕沙星和加替沙星的抗Mh活性较临床沿用的品种强;Mh对临床沿用的氟喹诺酮类药物有不同程度的耐药性.

Objective: To test the activity of fluoroquinolones against Mycoplasma hominis (Mh) for the guidance of rational use of antibiotics. Methods: Susceptibility of 103 clinical isolates of Mh to 6 fluoroquinolones were determined by broth microdilution method. Results: Among the 6 fluoroquinolones tested, sparfloxacin and gatifloxacin were the most active against Mh, the MIC 50s being 0.0325?mg /L and 0.25?mg /L, respectively; and MIC 90s being 1?mg /L for both drugs; the MIC 50 and MIC 90 of levofloxacin being 1?mg /L and 4?mg /L; while the MIC 50 and MIC 90 of ofloxacin and ciprofloxacin were 2?...