Interplay of disulfidptosis and the tumor microenvironment across cancers: implications for prognosis and therapeutic responses

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Xu, Shengshan*;Chen, Zizhou;Chen, Xiguang;Chu, Hongyu;Huang, Xufeng;...

通讯作者：

Xu, SS;Xu, Shengshan;Lu, ZM

作者机构：

[Xu, Shengshan; Xu, SS; Chen, Zizhou] Sun Yat Sen Univ, Affiliated Hosp 7, Sci Res Ctr, Shenzhen, Guangdong, Peoples R China.

[Xu, Shengshan; Xu, SS; Chen, Zizhou] Sun Yat Sen Univ, Affiliated Hosp 7, Dept Thorac Surg, Shenzhen, Guangdong, Peoples R China.

[Liu, Hejie; Lu, Zhuming; Xu, Shengshan; Lu, ZM; Xu, SS] Jiangmen Cent Hosp, Dept Thorac Surg, Jiangmen, Guangdong, Peoples R China.

[Chen, Xiguang] Univ South China, Affiliated Hosp 1, Dept Med Oncol, Hengyang, Hunan, Peoples R China.

[Chu, Hongyu] Jilin Univ, China Japan Union Hosp, Dept Gastrointestinal Colorectal & Anal Surg, Changchun, Jilin, Peoples R China.

通讯机构：

[Xu, SS ] S

[Lu, ZM ; Xu, SS] J

Sun Yat Sen Univ, Affiliated Hosp 7, Sci Res Ctr, Shenzhen, Guangdong, Peoples R China.

Sun Yat Sen Univ, Affiliated Hosp 7, Dept Thorac Surg, Shenzhen, Guangdong, Peoples R China.

Jiangmen Cent Hosp, Dept Thorac Surg, Jiangmen, Guangdong, Peoples R China.

语种：

英文

关键词：

Pan-cancer;Disulfidptosis;Prognosis;Immunotherapy;Tumor microenvironment

期刊：

BMC Cancer

ISSN：

1471-2407

年：

2025

卷：

期：

页码：

1-21

DOI：

10.1186/s12885-025-14246-1

基金类别：

This work was supported by the Medical Science Foundation of Jiangmen Central Hospital (J202401).

机构署名：

本校为其他机构

院系归属：

医学院

摘要：

The recent elucidation of disulfidptosis, a unique form of cell death, has opened new paths for the development of targeted cancer therapies. However, a thorough examination of disulfidptosis-related genes (DRGs) across various cancer types has been lacking. Our extensive analysis of DRGs through genomic, transcriptional, and immune profiling has yielded substantial insights. Utilizing The Cancer Genome Atlas (TCGA), we have identified key changes in gene expression, including alterations in copy number and DNA methylation, and evaluated their impact on cancer prognosis. We constructed a disul...

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Interplay of disulfidptosis and the tumor microenvironment across cancers: implications for prognosis and therapeutic responses

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