Mitophagy in cardiovascular disease

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Zhou, Hong;He, Lu;Xu, Gaosheng;Chen, Linxi*

通讯作者：

Chen, Linxi

作者机构：

[Zhou, Hong; Chen, Linxi] Univ South China, Hengyang Med Coll, Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, Inst Pharm & Pharmacol, Hengyang 421001, Hunan, Peoples R China.

[He, Lu] Univ South China, Affiliated Hosp 1, Dept Neurosurg, Hengyang, Hunan, Peoples R China.

[Xu, Gaosheng] Yueyang Maternal & Child Hlth Care Hosp, Dept Breast Surg, Yueyang 414000, Hunan, Peoples R China.

[Zhou, Hong] Univ South China, Affiliated Hosp 1, Dept Radiol, Hengyang, Hunan, Peoples R China.

[Chen, Linxi] Univ South China, Hengyang Med Coll, Inst Pharm & Pharmacol, Hengyang 421001, Peoples R China.

通讯机构：

[Chen, Linxi] U

Univ South China, Hengyang Med Coll, Inst Pharm & Pharmacol, Hengyang 421001, Peoples R China.

语种：

英文

关键词：

Atherosclerosis;Cardiac hypertrophy;Heart failure;Hypertension;Ischemiareperfusion injury;Mitophagy

期刊：

Clinica Chimica Acta

ISSN：

0009-8981

年：

2020

卷：

507

页码：

210-218

DOI：

10.1016/j.cca.2020.04.033

基金类别：

This study was supported by the National Natural Science Foundation of China ( 81803535 ). Heath and Family Planning Commission Science Foundation Projects of Hunan Province of China , Grant/Award Number: C20180187 ; Hunan Provincial Natural Science Foundation of China , Grant/Award Numbers: 2018JJ6119 ; Hunan Provincial Key Laboratory of tumor microenvironment responsive drug research , Hunan Provincial Science and Technology Department document (Approval number: 2019-56 ).

机构署名：

本校为第一且通讯机构

院系归属：

药学与生物科学学院

摘要：

Cardiovascular disease (CVD) leads to high morbidity and mortality rates worldwide. Accumulating evidence has revealed that mitochondria dysfunction is implicated in CVD, such as atherosclerosis (AS), hypertension, myocardial ischemia-reperfusion (MI/R) injury, myocardial infarction (MI), cardiac hypertrophy, heart failure (HF), dilated cardiomyopathy (DCM) and so on. Mitophagy is a mitochondrial quality control mechanism that eliminates damaged or superfluous mitochondria to maintain cardiac function in response to various stress and cardiac disease conditions. This article reviews the latest...

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