期刊论文

中文

辐射研究与辐射工艺学报

1000-3436

2012

30

4

237-241

国家自然科学基金(81072331)； 湖南省教育厅科研基金(07C619)资助；

本校为其他机构

研究铀矿尘所致人支气管上皮细胞遗传毒性以及茶多酚对细胞的防护作用,为铀矿尘的防护提供理论依据。将细胞分为3组:对照组、铀矿尘组(高中低剂量组)、茶多酚保护组,采用微核多核实验、彗星实验、HPRT基因突变检测及染色体分析研究铀矿尘对支气管上皮细胞的遗传毒性作用及茶多酚防护作用。BEAS-2B细胞经铀矿尘染毒后,与对照组相比,彗星细胞数(高剂量组156.75±8.26)、彗星尾长(高剂量组164.48±12.11μm)、尾距(高剂量组109.92±10.53)均显著意义的增加(p

To observe the genotoxicity induced by uranium dust in BEAS-2B cells and the protective effect of tea polyphenol,the cells were divided into three groups as control group,uranium dust group（high,medium and low dose group）,tea polyphenols protection group,using the micronucleus multicore experiments,comet assay,the HPRT gene mutation detection and analysis of chromosome studies of uranium dust bronchial epithelial cells with the genotoxic effects of tea polyphenols protective effect.BEAS-2B cells exposed to uranium ore dust,compared with the c...