STK25: a viable therapeutic target for cancer treatments?

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Chen, Ke-qian;Lei, Guan-lan;Ke, Bo-yi;Chen, Lu;Wang, Zong-bao;...

通讯作者：

Wang, SZ

作者机构：

[Wang, Shu-zhi; Chen, Ke-qian; Lei, Guan-lan; Ke, Bo-yi; Wang, Zong-bao; Chen, Lu] Univ South China, Inst Pharm & Pharmacol, Sch Pharmaceut Sci, Hengyang Med Sch,Dept Pharmacol, Hengyang, Peoples R China.

[Wang, Shu-zhi; Chen, Ke-qian; Lei, Guan-lan; Ke, Bo-yi; Wang, Zong-bao; Chen, Lu] Univ South China, Hunan Prov Cooperat Innovat Ctr Mol Target New Dru, Dept Pharmacol, Hengyang, Peoples R China.

[Wang, Shu-zhi; Wang, SZ] Univ South China, Inst Pharm & Pharmacol, Hunan Prov Cooperat Innovat Ctr Mol Target New Dru, Hengyang Med Sch,Sch Pharmaceut Sci,Dept Pharmacol, Hengyang 421001, Peoples R China.

通讯机构：

[Wang, SZ ] U

Univ South China, Inst Pharm & Pharmacol, Hunan Prov Cooperat Innovat Ctr Mol Target New Dru, Hengyang Med Sch,Sch Pharmaceut Sci,Dept Pharmacol, Hengyang 421001, Peoples R China.

语种：

英文

关键词：

autophagy, colorectal carcinoma, hepatocellular carcinoma, metabolic disease, neuroblastoma, prostate cancer, neuroblastoma, potential drugs, serine/threonine protein kinase 25

期刊：

ANTI-CANCER DRUGS

ISSN：

0959-4973

年：

2023

卷：

期：

页码：

995-1001

DOI：

10.1097/CAD.0000000000001490

基金类别：

This work was supported by the Scientific Research Project of the Hunan Provincial Department of Education (20K106) and the Project of the Hunan Provincial Health Committee (D202302048902).

机构署名：

本校为第一且通讯机构

院系归属：

药学与生物科学学院

摘要：

Serine/threonine protein kinase 25 (STK25) is a critical regulator of ectopic lipid storage, glucose and insulin homeostasis, fibrosis, and meta-inflammation. More and more studies have revealed a strong correlation between STK25 and human diseases. On the one hand, STK25 can affect glucose and fatty acid metabolism in normal cells or tumors. On the other hand, STK25 participates in autophagy, cell polarity, cell apoptosis, and cell migration by activating various signaling pathways. This article reviews the composition and function of STK25, the energy metabolism and potential drugs that may ...

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STK25: a viable therapeutic target for cancer treatments?

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