Enhancing the load following capacity of Nuclear Power Plants (NPPs) remains a challenge. This paper focuses on designing a fixed-time stable controller for load following operation of a Pressurized Water Reactor (PWR) with compound disturbances. To compensate the limitation of current measuring techniques, an adaptive learning observer is firstly proposed to estimate the hard-to-measure states like Xenon concentration, Iodine concentration, average reactor fuel temperature and the compound disturbances of the PWR system. Based on these important information, in order to ensure that the output...