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ROS-mediated Therapeutics Combined with Metal-based Porphyrin Nanoparticles and their Applications in Tumor Treatment.

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成果类型:
期刊论文
作者:
Yang, Lingyan;Shi, Lei;Liu, Yihui;Liu, Zhenhua;Tian, Zejie;...
作者机构:
[Liu, Yunmei; Zhang, Jiayao; Yang, Lingyan; Li, Hui; Shi, Lei; Liu, Zhenhua; Tian, Zejie] Institute of Pharmacy & Pharmacology, Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, Hunan Provincial Key Laboratory of Tumor Microenvironment Responsive Drug Research, University of South China, Hengyang City, Hunan Province 421001, China
[Liu, Yihui] The second Hospital, University of South China, Hengyang City, Hunan Province, 421001, China
[He, Jun] Institute of Chemistry & Chemical Engineering, University of South China, Hengyang City, Hunan Province, 421001, China
语种:
英文
关键词:
Chemodynamic therapy(CDT);Nanomedicines;Photodynamic therapy(PDT);Porphyrins;ROS-mediated cancer treatments;Treatment for cancer
期刊:
CURRENT MEDICINAL CHEMISTRY
ISSN:
0929-8673
年:
2023
机构署名:
本校为第一机构
院系归属:
药学与生物科学学院
摘要:
High concentrations of reactive oxygen species (ROS) can disrupt cell structure and induce apoptosis and necrosis of tumor cells. Photodynamic therapy (PDT) and chemodynamic therapy (CDT) are two cancer treatments mediated by reactive oxygen species. Oxygen molecules (O2 ) are one of the indispensable factors in PDT and hypoxic tumor sites limit its application. However, another ROS-mediated method, CDT, can generate •OH and O2 in situ by Fenton reaction or Fenton-like reaction. Synergistic PDT/CDT therapy is a strategy to overcome the limitat...

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